Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Summary of findings table (sensitivity analysis): interventions esophageal and GE‐junction carcinoma vs gastric carcinoma

Sensitivity analysis, meta‐regression analysis, second part · palliative participants with esophageal and GE‐junction carcinoma or gastric carcinoma

Summary of findings table (sensitivity analysis): interventions… probably leads to lower sensitivity analysis, meta‐regression analysis, second part compared with gastric carcinoma (moderate certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Significant adverse effects: significant bleeding requiring intervention, severe pain, iatrogenic injury · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Sinonasal debridement vs no debridement

Adhesion rate · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement may leads to lower adhesion rate compared with no debridement (low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in failure to maintain clinical or endoscopic remission compared with comparator 5‐aminosalicylic acid formulation (low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether oral 5‐aminosalicylic acid changes withdrawal due to adverse events compared with comparator 5‐aminosalicylic acid formulation (very low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Exclusion/withdrawal after entry · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in exclusion/withdrawal after entry compared with comparator 5‐aminosalicylic acid formulation (moderate certainty).

1 finding from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Functional success, defined as the relief of epiphora · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in functional success, defined as the relief of epiphora compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Anatomic success, defined as patency to lacrimal irrigation · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in anatomic success, defined as patency to lacrimal irrigation compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone

Ostium size on nasal endoscopy · nasolacrimal duct obstruction

Mitomycin C dacryocystorhinostomy showed no clear difference in ostium size on nasal endoscopy compared with dacryocystorhinostomy alone (low certainty).

2 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Neurodevelopmental outcomes · preterm born neonates

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

1 finding from 1 review