Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 76 findings · 11 reviews · Effective Practice and Organisation of Care

No studies found 1 · 1.3%GRADE not reported 0 · 0%Very low 34 · 44.7%Low 21 · 27.6%Moderate 17 · 22.4%High 3 · 3.9%

Primary health professional‐led psychological interventions vs usual care or no treatment

Depression symptoms (1 to 6 months post intervention) Hopkins Symptom Checklist ‐ depression (higher score = higher severity) · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes depression symptoms (1 to 6 months post intervention) Hopkins… compared with usual or no care (very low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Functional impairment · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes functional impairment (1 to 6 months post intervention) Locally… compared with usual or no care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Functional impairment ‐ not measured · adults with common mental disorders

Lay health worker‐led psychological interventions showed no clear difference in functional impairment/disability ‐ intermediate term (1 to 6 months… compared with usual care (low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months post intervention) Defined by AUDIT score < 8 (RR > 1 denotes higher likelihood of recovery) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Service utilisation ‐ Unplanned hospitalisation in past 12 months (RR > 1 denotes higher risk of hospitalisation) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes service utilisation ‐ Unplanned hospitalisation in past 12 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes adverse events ‐ death in past 12 months (RR > 1 denotes higher risk… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Caregiver burden · people with severe mental disorders

Lay health worker‐ showed no clear difference in caregiver burden symptom severity ‐ immediately post intervention… compared with specialist‐led care (low certainty).

1 finding from 1 review

Implementation interventions vs no intervention

HRQoL at 6 or 12 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: HRQoL (EQ‐5D: –0.59 to 1, higher score… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Patient health status: ADL (Barthel Index, 0–20, higher score = better) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: ADL (Barthel Index, 0–20, higher score =… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Patient health status: psychological well‐being (GHQ‐12, 0–36, higher score = worse) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: psychological well‐being (GHQ‐12, 0–36,… compared with no intervention (low certainty).

1 finding from 1 review

Non‐specialist‐led vs specialist‐led follow‐up after primary cancer treatment

Depressive symptoms · adult cancer survivors from the following cancer sites: breast, colon, colorectal, endometrial, ovarian, cervical, melanoma and oesophageal

Non‐specialist‐led showed no clear difference in depression (at 12 months) HADS‐Depression subscale (higher scores… compared with specialist‐led follow‐up after primary cancer treatment (high certainty).

1 finding from 1 review