First-time bracket failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Resin-modified glass ionomer cement showed no difference in first-time bracket failure, with certainty not graded.
1 finding from 1 review
No differences were observed in the proportions of patients experiencing first-time bracket failures when participants were bonded with either resin adhesive or RM-GIC (p > 0.05).
1 study · 197 participants
GRADE not reported
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Chitosan and TiO2 adhesive reduced S. mutans counts, with certainty not graded.
1 finding from 1 review
Experimental group: significant decrease in S. mutans count was observed at the time points of 1 day, 2 months, and 6 months for both maxillary lateral incisor (p = 0.01) and maxillary second premolar teeth (p = 0.001).
1 study · 24 participants
GRADE not reported
New white spot lesion incidence (and first-time bracket bond failure) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single multicenter RCT found resin-modified glass-ionomer cement did not reduce new white spot lesions or bond failures versus conventional composite (ungraded).
1 finding from 1 review
Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two small RCTs gave inconsistent results for TiO2-modified adhesives/composites on enamel demineralization (one favorable on DIAGNOdent, one no difference in mineral content); ungraded.
1 finding from 1 review
White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no WSL-rate difference versus conventional adhesive, with certainty not graded.
1 finding from 1 review
There was no significant difference among the WSL rates of the Clearfil, Opal Seal, and Transbond XT adhesives (p > 0.05).
1 study · 15 participants
GRADE not reported
Enamel mineral content · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Chitosan and TiO2 adhesive showed no enamel mineral-content difference, with certainty not graded.
1 finding from 1 review
Zinc polycarboxylate cement vs Any other orthodontic band adhesive
Outcome not reported · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…
The review found no eligible studies for this question.
1 finding from 1 review
Zinc silicophosphate cement vs Any other orthodontic band adhesive
Outcome not reported · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…
The review found no eligible studies for this question.
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Glass ionomer cement did not show a statistically significant difference in new white spot lesions versus resin adhesive (very low certainty).
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
There is no clear difference in WSL initiation between glass ionomer cement and resin adhesive for bracket bonding (RR 0.72, not significant); certainty of evidence is very low.
1 finding from 1 review
White spot lesion area · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL area, with certainty not graded.
1 finding from 1 review
There was no significant difference in the WSL area between the two groups, with the mean WSL area measuring 161.3 mm2 in the Opal Seal group and 1361.2 mm2 in the conventional group.
1 study · 56 participants
GRADE not reported
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
TiO2-modified composite showed no S. mutans difference, with certainty not graded.
1 finding from 1 review
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no difference in WSL incidence, with certainty not graded.
1 finding from 1 review
The incidence of WSLs in the Clearfil (CF) group was 8.03%, while in the Transbond (TB) group, it was 9.24% with no significant difference (p = 0.82).
1 study · 35 participants
GRADE not reported
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal had fewer DIAGNOdent-measured lesions, with certainty not graded.
1 finding from 1 review
Opal Seal group showed fewer WSLs compared to the Transbond group, with initial demineralization rates of 1.3% and 3.9%, and caries lesion rates of 0.2% and 1.3%, respectively (p <0.03).
1 study · 56 participants
GRADE not reported
Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no difference in photographic WSL severity, with certainty not graded.
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer favored lower demineralization scores, but certainty was not graded.
1 finding from 1 review
Statistically significant scores in favor of the nCaF2 primer at T1, T3, and T6 (p-value = 0.000).
1 study · 31 participants
GRADE not reported
Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no difference in bracket failure, with certainty not graded.
1 finding from 1 review
No significant differences were observed in bracket failure rates among different primers, dental arches, bracket types, or sexes.
1 study · 56 participants
GRADE not reported
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The self-etch primer system had higher WSL incidence than the conventional system, with certainty not graded.
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single small split-mouth RCT found the nCaF2-containing primer reduced demineralization (DIAGNOdent) but showed no significant clinical white spot lesion difference at debonding (ungraded).
1 finding from 1 review
Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer showed no clinical photographic WSL difference at debonding, with certainty not graded.
1 finding from 1 review