Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 52 findings · 3 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 7 · 13.5%Very low 21 · 40.4%Low 24 · 46.2%Moderate 0 · 0%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes PNALD/cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review