What do systematic reviews say?

Doxycycline vs tetracycline

• Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 116 participants
  Low

Doxycycline vs tetracycline

The review found no eligible studies for this question.

• Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Doxycycline vs quinolones

• Antimicrobial drugs for treating cholera 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 126 participants
  Low

Doxycycline vs quinolones

• Antimicrobial drugs for treating cholera 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 435 participants
  Low

Doxycycline vs quinolones

Doxycycline may leads to higher bacteriological failure compared with quinolones (low certainty).

• Antimicrobial drugs for treating cholera 2014 · Cochrane Headline outcomes only
  RR 5.84 [2.7, 12.65]
  4 studies · 386 participants
  Low

Doxycycline+Rifampicin vs Doxycycline+Streptomycin

Doxycycline+Rifampicin probably leads to higher total treatment failure compared with doxycycline+Streptomycin (moderate certainty).

• Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
  RR 1.91 [1.07, 3.42]
  7 studies · 567 participants
  Moderate

Doxycycline+Rifampicin vs Doxycycline+Streptomycin

Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with doxycycline+Streptomycin (low certainty).

• Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
  RR 1.38 [0.99, 1.92]
  5 studies · 473 participants
  Low

Doxycycline+Streptomycin vs Doxycycline+Gentamycin

Doxycycline+Streptomycin showed no clear difference in total treatment failure compared with doxycycline+Gentamycin (low certainty).

• Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
  OR 1.85 [0.84, 4.08]
  2 studies · 345 participants
  Low

Doxycycline+Streptomycin vs Doxycycline+Gentamycin

It is very uncertain whether doxycycline+Streptomycin changes minor adverse drug reactions compared with doxycycline+Gentamycin (very low certainty).

• Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
  RR 0.85 [0.6, 1.22]
  2 studies · 345 participants
  Very low

Doxycycline + SRP vs Metronidazole + SRP

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD 0.34 [-0.08, 0.76]
  3 studies · 75 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD 1.10 [0.36, 1.84]
  1 study · 27 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.12 [-0.72, 0.49]
  2 studies · 49 participants
  GRADE not reported

Doxycycline + SRP vs SRP

It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -0.80 [-1.49, -0.11]
  1 study · 22 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.61 [-1.14, -0.08]
  3 studies · 65 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.15 [-0.53, 0.83]
  2 studies · 43 participants
  GRADE not reported

Doxycycline + SRP vs SRP

Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.10 [-0.29, 0.50]
  2 studies · 43 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -1.00 [-1.78, -0.22]
  1 study · 22 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.43 [-0.88, 0.01]
  3 studies · 65 participants
  GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Doxycycline + SRP vs Metronidazole + SRP

Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD 0.38 [0.00, 0.76]
  3 studies · 75 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD 1.00 [0.30, 1.70]
  1 study · 27 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.16 [-0.56, 0.24]
  2 studies · 49 participants
  GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported adverse events
  Studies not reported
  No studies found

Doxycycline + SRP vs Metronidazole + SRP

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.05 [-0.22, 0.12]
  1 study · 22 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.07 [-0.29, 0.15]
  1 study · 22 participants
  GRADE not reported

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD 0.17 [-1.28, 1.62]
  1 study · 20 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.20 [0.06, 0.33]
  2 studies · 50 participants
  GRADE not reported

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.14 [-0.12, 0.40]
  2 studies · 50 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD 0.23 [-0.41, 0.87]
  1 study · 20 participants
  GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Doxycycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found