Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

100 questions · 105 findings · 18 reviews

No studies found 18 · 17.1%GRADE not reported 8 · 7.6%Very low 20 · 19%Low 34 · 32.4%Moderate 18 · 17.1%High 7 · 6.7%

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Effect of severity of PDC displacement towards the midline on the proportion of successful eruptions · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Incidence of successfully erupted PDC that were favourably positioned · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

Double primary (canine and first molar) tooth extraction showed no clear difference in incidence of successfully erupted PDC that were favourably positioned compared with single primary (canine) tooth extraction; GRADE not reported.

3 findings from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Any other adverse effects of the interventions, such as gingival disease and demineralisation · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Number of participants referred for surgical exposure of the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

It is very uncertain whether double primary (canine and first molar) tooth extraction changes number of participants referred for surgical exposure of the PDC compared with single primary (canine) tooth extraction (very low certainty).

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Costs and cost‐effectiveness · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Reported improvement in the position of the ectopic canine measured from radiographs · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Patient‐reported outcome measures (PROMs) · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Time taken for the canine to erupt into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Overall treatment time wearing orthodontic appliances · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP pancreatitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) may leads to higher post‐ERCP pancreatitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

CBD cannulation success with the randomised technique (before the use of rescue techniques) · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in CBD cannulation success with the randomised technique (before the… compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Overall success of cannulation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in overall cannulation success compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP bleeding · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP bleeding compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP perforation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP perforation compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP cholangitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP cholangitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

All‐cause mortality · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in mortality compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Double‐dose adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver transplantation vs liver transplantation

All‐cause mortality · participants with unresectable hepatocellular carcinoma

Double‐dose adenovirus‐thymidine kinase with ganciclovir… may leads to lower all‐cause mortality compared with liver transplantation (low certainty).

1 finding from 1 review