Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth
Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).
1 finding from 1 review
RR 0.23 [0.08, 0.69]
2 studies
GRADE not reported
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Partial caries removal reduced the reported risk of pulp exposure versus complete caries removal in primary teeth (RR 0.24; ungraded).
1 finding from 1 review
RR 0.24 [0.06, 0.90]
262 participants
GRADE not reported
Diagnostic odds ratio (DOR) by subgroup: Medium dentine-caries prevalence (15% to 34%) (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Diagnostic odds ratio (DOR) by subgroup: Low dentine-caries prevalence (<=14%) (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Diagnostic odds ratio (DOR) by subgroup: High dentine-caries prevalence (>=35%) (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Arrest of dentine caries · Children with active dentine caries
One randomised trial found nano-silver fluoride arrested dentine caries without the black staining seen with silver diamine fluoride; ungraded.
1 finding from 1 review
Arrest of dentine caries · Children with active dentine caries in primary teeth
One study reported 30% silver diamine fluoride effectively arrested dentine caries in primary teeth; ungraded.
1 finding from 1 review
Arrest of dentine caries · Children with active dentine caries
One trial found a single application of 12% silver diamine fluoride did not arrest dentine caries; ungraded.
1 finding from 1 review
Caries lesion arrestment · Children with dentin caries lesions in the outer half of dentin on occlusal surfaces of primary teeth
Resin sealing and conventional restorative treatment (resin composite) did not differ significantly for caries lesion arrestment in outer-half occlusal dentin caries of primary teeth (2 studies; low certainty).
1 finding from 1 review
Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
1 finding from 1 review
Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18…
2 studies · 25 participants
GRADE not reported
Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm
Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible).
1 finding from 1 review
Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)…
2 studies · 9 participants
GRADE not reported
Restoration failure · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth
It is very uncertain whether partial caries removal (single stage; residual dentinal caries… changes failure of restorations compared with complete caries removal (very low certainty).
1 finding from 1 review
Signs or symptoms of pulpal disease · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth
Partial caries removal (single stage; residual dentinal caries… showed no clear difference in signs or symptoms of pulpal disease compared with complete caries removal (low certainty).
1 finding from 1 review
Negative LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced proximal caries was 0.58 (95% CI 0.52 to 0.65) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of radiographic detection for all (initial and advanced) occlusal caries was 91.4% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
NPV 91.4
9 studies
GRADE not reported
NPV 85.0
11 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced occlusal caries was 0.53 (95% CI 0.46 to 0.62) (ungraded).
3 findings from 1 review
Negative LR 0.53 [0.46, 0.62]
44 studies
GRADE not reported
Negative LR 0.51 [0.44, 0.6]
38 studies
GRADE not reported
Negative LR 0.54 [0.46, 0.63]
36 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, the negative lr of radiographic detection for all (initial and advanced) proximal caries was 0.65 (95% CI 0.57 to 0.74) (ungraded).
3 findings from 1 review
Negative LR 0.65 [0.57, 0.74]
31 studies
GRADE not reported
Negative LR 0.65 [0.57, 0.73]
34 studies
GRADE not reported
Negative LR 0.63 [0.56, 0.72]
38 studies
GRADE not reported
Positive LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced proximal caries was 9.82 (95% CI 7.3 to 13.3) (ungraded).
3 findings from 1 review
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Specificity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled specificity of radiographic detection for advanced proximal caries was 95.5% (95% CI 94 to 97) (ungraded).
3 findings from 1 review
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) occlusal caries was 1.74 (95% CI 1.3 to 2.4) (ungraded).
3 findings from 1 review
Positive LR 1.74 [1.3, 2.4]
14 studies
GRADE not reported
Positive LR 2.36 [1.4, 4.1]
9 studies
GRADE not reported
Positive LR 2.02 [1.4, 2.9]
11 studies
GRADE not reported