Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
1 finding from 1 review
Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18…
2 studies · 25 participants
GRADE not reported
Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm
Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible).
1 finding from 1 review
Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)…
2 studies · 9 participants
GRADE not reported
Negative LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced proximal caries was 0.58 (95% CI 0.52 to 0.65) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of radiographic detection for all (initial and advanced) occlusal caries was 91.4% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
NPV 91.4
9 studies
GRADE not reported
NPV 85.0
11 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced occlusal caries was 0.53 (95% CI 0.46 to 0.62) (ungraded).
3 findings from 1 review
Negative LR 0.53 [0.46, 0.62]
44 studies
GRADE not reported
Negative LR 0.51 [0.44, 0.6]
38 studies
GRADE not reported
Negative LR 0.54 [0.46, 0.63]
36 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, the negative lr of radiographic detection for all (initial and advanced) proximal caries was 0.65 (95% CI 0.57 to 0.74) (ungraded).
3 findings from 1 review
Negative LR 0.65 [0.57, 0.74]
31 studies
GRADE not reported
Negative LR 0.65 [0.57, 0.73]
34 studies
GRADE not reported
Negative LR 0.63 [0.56, 0.72]
38 studies
GRADE not reported
Positive LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced proximal caries was 9.82 (95% CI 7.3 to 13.3) (ungraded).
3 findings from 1 review
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Specificity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled specificity of radiographic detection for advanced proximal caries was 95.5% (95% CI 94 to 97) (ungraded).
3 findings from 1 review
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) occlusal caries was 1.74 (95% CI 1.3 to 2.4) (ungraded).
3 findings from 1 review
Positive LR 1.74 [1.3, 2.4]
14 studies
GRADE not reported
Positive LR 2.36 [1.4, 4.1]
9 studies
GRADE not reported
Positive LR 2.02 [1.4, 2.9]
11 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for all (initial and advanced) occlusal caries was 0.79 (95% CI 0.65 to 0.96) (ungraded).
3 findings from 1 review
Negative LR 0.79 [0.65, 0.96]
14 studies
GRADE not reported
Negative LR 0.76 [0.58, 0.99]
9 studies
GRADE not reported
Negative LR 0.75 [0.6, 0.94]
11 studies
GRADE not reported
Sensitivity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled sensitivity of radiographic detection for advanced proximal caries was 44.4% (95% CI 38 to 51) (ungraded).
3 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Specificity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for advanced occlusal caries was 91.4% (95% CI 88 to 94) (ungraded).
3 findings from 1 review
Specificity 91.4 [88, 94]
36 studies
GRADE not reported
Specificity 89.3 [86, 92]
44 studies
GRADE not reported
Specificity 89.1 [86, 92]
38 studies
GRADE not reported
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for all (initial and advanced) occlusal caries was 84.8% (95% CI 77 to 90) (ungraded).
3 findings from 1 review
Specificity 84.8 [77, 90]
9 studies
GRADE not reported
Specificity 80.4 [72, 87]
11 studies
GRADE not reported
Specificity 77.8 [70, 84]
14 studies
GRADE not reported
Specificity for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for all (initial and advanced) proximal caries was 91.7% (95% CI 90 to 93) (ungraded).
3 findings from 1 review
Specificity 91.7 [90, 93]
34 studies
GRADE not reported
Specificity 90.0 [87, 92]
38 studies
GRADE not reported
Specificity 92.5 [91, 94]
31 studies
GRADE not reported
Positive LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced occlusal caries was 5.87 (95% CI 4.3 to 8.0) (ungraded).
3 findings from 1 review
Positive LR 5.87 [4.3, 8.0]
36 studies
GRADE not reported
Positive LR 4.9 [3.7, 6.5]
44 studies
GRADE not reported
Positive LR 5.96 [3.7, 6.6]
38 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) proximal caries was 4.3 (95% CI 3.4 to 5.5) (ungraded).
3 findings from 1 review
Positive LR 4.3 [3.4, 5.5]
38 studies
GRADE not reported
Positive LR 4.89 [3.9, 6.2]
34 studies
GRADE not reported
Positive LR 5.34 [4.2, 6.8]
31 studies
GRADE not reported
Sensitivity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled sensitivity of radiographic detection for advanced occlusal caries was 54.2% (95% CI 47 to 61) (ungraded).
3 findings from 1 review
Sensitivity 54.2 [47, 61]
38 studies
GRADE not reported
Sensitivity 52.3 [44, 60]
44 studies
GRADE not reported
Sensitivity 50.8 [43, 59]
36 studies
GRADE not reported
Sensitivity for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, pooled sensitivity of radiographic detection for all (initial and advanced) proximal caries was 43.2% (95% CI 36 to 51) (ungraded).
3 findings from 1 review
Sensitivity 43.2 [36, 51]
38 studies
GRADE not reported
Sensitivity 40.2 [32, 48]
31 studies
GRADE not reported
Sensitivity 40.5 [33, 48]
34 studies
GRADE not reported
NPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the Egyptian public health clinic setting, the negative predictive value of radiographic detection for advanced occlusal caries was 89.3% at an assumed prevalence of 19.0% (ungraded).
2 findings from 1 review
NPV 89.3
38 studies
GRADE not reported
NPV 94.3
36 studies
GRADE not reported
PPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of radiographic detection for all (initial and advanced) occlusal caries was 22.6% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
PPV 22.6
9 studies
GRADE not reported
PPV 32.1
11 studies
GRADE not reported