evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

470 questions · 477 findings · 110 reviews · Headline outcomes only

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 68 · 14.3%GRADE not reported 41 · 8.6%Very low 143 · 30%Low 133 · 27.9%Moderate 73 · 15.3%High 19 · 4%

Discontinuation with high‐intensity psychological interventions vs continuation

Risk of relapse (as defined by study authors) (HR) · participants with long‐term antidepressants for depressive disorders

Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Lack of symptom control · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes lack of symptom control compared with continued use (very low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review

Discontinuation by no treatment/placebo of antihypertensives vs continuation

Fatal or nonfatal myocardial infarction · Older adults, 50 years and older

It is very uncertain whether discontinuation by no treatment/placebo of antihypertensives changes myocardial infarction (fatal and nonfatal) compared with continuation (very low certainty).

1 finding from 1 review