Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

60 questions · 62 findings · 12 reviews · Headline outcomes only

No studies found 8 · 12.9%GRADE not reported 0 · 0%Very low 14 · 22.6%Low 29 · 46.8%Moderate 7 · 11.3%High 4 · 6.5%

Combined steroid and antibiotic therapy vs antibiotics alone

Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).

2 findings from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of PEa (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of PEa (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of DVTc (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of DVTc (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedingd (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of major bleedingf (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingf (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of PEa (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of PEa (early postoperative period) compared with pharmacological prophylaxis alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of DVTc (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis leads to lower incidence of DVTc (early postoperative period) compared with pharmacological prophylaxis alone (high certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedinge (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of major bleedingg (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingg (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).

1 finding from 1 review