Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 55 findings · 8 reviews · Headline outcomes only

No studies found 12 · 21.8%GRADE not reported 0 · 0%Very low 8 · 14.5%Low 21 · 38.2%Moderate 14 · 25.5%High 0 · 0%

Nicotinamide vs clindamycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with clindamycin (low certainty).

1 finding from 1 review

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review