Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 93 findings · 12 reviews · Schizophrenia

No studies found 15 · 16.1%GRADE not reported 11 · 11.8%Very low 43 · 46.2%Low 12 · 12.9%Moderate 12 · 12.9%High 0 · 0%

CHLORPROMAZINE vs RESERPINE

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in leaving the study early ‐ due to adverse effects (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Behaviour: Not improved ‐ general (medium term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in behaviour: Not improved ‐ general (medium term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs placebo

Global state: no overall improvement (psychiatrist ‐ rated) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes global state: no overall improvement (psychiatrist ‐ rated) compared with PLACEBO (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs placebo

Behaviour: deteriorated/ disturbed/un‐cooperative · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes behaviour: deteriorated/ disturbed/un‐cooperative compared with PLACEBO (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Global outcome: Number of additional injections ‐ 2‐4 injections · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 2‐4 injections compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Global outcome: Number of additional injections ‐ 5 or more · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 5 or more compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes adverse effects ‐ cardiovascular ‐ hypotension compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs MEDIUM DOSE (401 mg/day to 800 mg/day)

Global state: no improvement ‐ short term · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) changes global state: no improvement ‐ short term compared with MEDIUM DOSE (401 mg/day to 800 mg/day) (very low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs HIGH DOSE (> 800 mg/day ‐ all medium term)

Behaviour: deterioration of behaviour (categorised as reason to leave early) · schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) may leads to higher behaviour: deterioration of behaviour (categorised as reason to… compared with HIGH DOSE (> 800 mg/day ‐ all medium term) (low certainty).

1 finding from 1 review