What do systematic reviews say?

MS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 12 participants
  GRADE not reported

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.28 [0.69, 2.35]
  5 studies · 399 participants
  Low

Fish oil lipid emulsion (LE) vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 261 participants
  Low

MOFS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 347 participants
  Very low

Fish oil lipid emulsion (LE) vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 374 participants
  Very low

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.02 [0.7, 1.5]
  4 studies · 341 participants
  Low

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.92 [0.61, 1.39]
  5 studies · 373 participants
  Low

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.43 [0.06, 2.85]
  3 studies · 256 participants
  Low

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.8 [0.29, 2.16]
  4 studies · 341 participants
  Low

MOFS‐LE vs S‐LE

MOFS‐LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.02 [0.7, 1.49]
  4 studies · 314 participants
  Low

MOFS‐LE vs S‐LE

MOFS‐LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.94 [0.62, 1.42]
  5 studies · 346 participants
  Low

MOFS‐LE vs S‐LE

MOFS‐LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.43 [0.06, 2.85]
  3 studies · 256 participants
  Low

MOFS‐LE vs S‐LE

MOFS‐LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.78 [0.29, 2.13]
  4 studies · 314 participants
  Low

MFS‐LE vs S‐LE

MFS‐LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 5 [0.25, 99.95]
  1 study · 60 participants
  Low

MFS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Low