Findings

What do systematic reviews say?

55 questions · 57 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 4 · 7%Very low 16 · 28.1%Low 37 · 64.9%Moderate 0 · 0%High 0 · 0%

Alternative lipid emulsion (LE) vs another alternative‐LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 2.9 [0.12, 68.5]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Death at hospital discharge · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs another alternative‐LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MS‐LE vs… compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.77 [0.23, 2.6]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.93 [0.65, 5.73]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

2 findings from 2 reviews · compare the 2 reviews

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Low
Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 497 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in any BPD – OS‐LE vs S‐LE (sensitivity analysis) compared with soybean oil‐based LE (S‐LE) (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.01 [0.57, 1.79]
3 studies · 197 participants
Low
Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.84 [0.63, 1.12]
7 studies · 602 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Growth rate – MS‐LE vs S‐LE · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (any definition) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.26, 3.86]
4 studies · 261 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.15, 6.82]
2 studies · 159 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Death at hospital discharge · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in death before discharge – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.21, 4.82]
3 studies · 224 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Death of baby (up to discharge) · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs S‐LE

Any ROP – OS‐LE vs S‐LE · Parenterally fed preterm infants

It is very uncertain whether alternative lipid emulsion (LE) changes any ROP – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.98 [0.67, 1.43]
3 studies · 142 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Culture‐positive sepsis · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in culture‐positive sepsis – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.22 [0.54, 2.78]
2 studies · 164 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 310 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

All alternative LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.17 [0.66, 2.07]
7 studies · 623 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 484 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.9 [0.66, 1.23]
9 studies · 674 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.43 [0.06, 2.85]
3 studies · 256 participants
Very low