Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 92 findings · 9 reviews · Headline outcomes only

No studies found 45 · 48.9%GRADE not reported 1 · 1.1%Very low 4 · 4.3%Low 21 · 22.8%Moderate 14 · 15.2%High 7 · 7.6%

Vitamin C vs allopurinol

Joint pain reduction ‐ not reported · participants with chronic gout and sUA level > 0.36mmol/L

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C vs allopurinol

Participant global assessment · participants with chronic gout and sUA level > 0.36mmol/L

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C vs allopurinol

Tophus regression · participants with chronic gout and sUA level > 0.36mmol/L

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C vs allopurinol

Acute gout attacks · participants with chronic gout and sUA level > 0.36mmol/L

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Incidence of clinical tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase showed no clear difference in incidence of clinical tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Mortality due to tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase may leads to lower mortality due to tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome

It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).

1 finding from 1 review

Probenecid vs allopurinol

Acute gout attacks · people with chronic gout

Probenecid showed no clear difference in acute gout attacks compared with allopurinol (low certainty).

1 finding from 1 review

Probenecid vs allopurinol

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review