Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,411 questions · 2,571 findings · 265 reviews

No studies found 543 · 21.1%GRADE not reported 169 · 6.6%Very low 676 · 26.3%Low 731 · 28.4%Moderate 399 · 15.5%High 53 · 2.1%

Self‐management interventions vs usual care

Courses of oral corticosteroids · patients with chronic obstructive pulmonary disease

Self‐management interventions including action plans for exacerbations showed no clear difference in courses of oral steroids compared with usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

Proportion of patients receiving platelets · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower proportion of patients receiving platelets compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

Rate of surgical reintervention · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in rate of surgical reintervention compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… may leads to lower mortality compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Proportion of patients receiving PRBCs · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… may leads to lower proportion of patients receiving PRBCs compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Proportion of patients receiving FFP · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… showed no clear difference in proportion of patients receiving FFP compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Proportion of patients receiving platelets · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… showed no clear difference in proportion of patients receiving platelets compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) in combination with SLT or other devices vs clinical judgement or usual care

Rate of surgical reintervention · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) in… may leads to lower rate of surgical reintervention compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in mortality compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

Proportion of patients receiving PRBCs · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in proportion of patients receiving PRBCs compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs clinical judgement or usual care

Proportion of patients receiving FFP · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower proportion of patients receiving FFP compared with clinical judgement or usual care (low certainty).

1 finding from 1 review

Alcohol‐based handrub vs usual care

Incidence of (study author‐defined) suspected infection within the first 28 days of life · Neonates and caregivers

It is very uncertain whether alcohol‐based handrub changes incidence of suspected infections (author‐defined) within the first… compared with usual care (very low certainty).

1 finding from 1 review

Four per cent chlorhexidine + hand hygiene promotion vs usual care

Authors reported adverse outcomes (events without hospitalisation) · Neonates and caregivers

It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes authors reported adverse outcomes (events without hospitalisation) compared with usual care (very low certainty).

1 finding from 1 review