Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.17 [-0.3, -0.04]
Studies not reported
Low
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).
1 finding from 1 review
SMD -0.26 [-0.31, -0.21]
41 studies
High
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
It is very uncertain whether 2400 to 2800 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1000 to 1250 ppm F toothpaste (very low certainty).
1 finding from 1 review
SMD -0.12 [-0.25, 0.01]
3 studies
Very low
Proportion developing new caries · Adults with mature permanent dentition (aged 18 to 93 years at study start)
The review found no eligible studies for this question.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.29 [-0.49, -0.08]
Studies not reported
Low
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste probably leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (moderate certainty).
1 finding from 1 review
SMD -0.08 [-0.14, -0.01]
10 studies
Moderate
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.23 [-0.5, 0.05]
Studies not reported
Low
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.2 [-0.46, 0.05]
Studies not reported
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
SMD -0.12 [-0.31, 0.07]
2 studies
Low
Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.28 [-0.47, -0.09]
Studies not reported
Low
Unmet dental treatment need · Children aged 1-18 years
Narrative reports from 6 studies suggested greater unmet dental treatment need in children with learning disabilities (5 of 6 studies), but no quantitative data were available (certainty not graded).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children with dental caries
Oral-health promotion programs were associated with markedly lower odds of DMFT/S in children (OR 0.19, 95% CI 0.10 to 0.39; ungraded, very high heterogeneity I2=98.5%).
1 finding from 1 review
OR 0.19 [0.10, 0.39]
8 studies
GRADE not reported
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with MTA than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 AR teeth): MTA 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; the 4 abscess-remedy failures occurred at 3 months; difference statistically…
1 study · 40 participants
GRADE not reported
Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1 finding from 1 review
Adverse effects of toothpaste · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 1450 to 1500 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD 0.05 [-0.19, 0.3]
Studies not reported
Low
Adverse effects of toothpaste · Adults with mature permanent dentition (aged 18 to 93 years at study start)
The review found no eligible studies for this question.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single 3-arm RCT found no difference in pulpotomy success between MTA and triple antibiotic paste (both 100%; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 TAP teeth): 100% clinical and radiographic success in both MTA and TAP at all follow-ups (1-24 months); no difference between groups; not pooled
1 study · 40 participants
GRADE not reported