Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
Antihypertensive drug therapy may leads to lower total cardiovascular mortality + morbidity compared with control (low certainty).
1 finding from 1 review
Cerebrovascular mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
Antihypertensive drug therapy may leads to lower cerebrovascular mortality + morbidity compared with control (low certainty).
1 finding from 1 review
Coronary heart disease mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
Antihypertensive drug therapy showed no clear difference in coronary heart disease mortality + morbidity compared with control (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
It is very uncertain whether antihypertensive drug therapy changes withdrawal due to adverse events compared with control (very low certainty).
1 finding from 1 review
Decrease in SBP5 at end of 1 year · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
1 finding from 1 review
Decrease in DBP6 at end of 1 year · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
1 finding from 1 review
Intervention not reported
Change in BMI (kg/m²) · children (aged 6 to 11 years) being overweight or obese
1 finding from 1 review
Intervention not reported
Adverse events (serious adverse events) · children (aged 6 to 11 years) being overweight or obese
The intervention showed no clear difference in adverse events (serious adverse events) (low certainty).
1 finding from 1 review
Intervention not reported
Change in health‐related quality of life (SMD) Parent‐reported measures Instruments: PedsQL parent proxy: 23 items that yield total, physical summary, and psychosocial summary scores, each with a possible range of 0‐100 (100 = best possible health... · children (aged 6 to 11 years) being overweight or obese
1 finding from 1 review
Intervention not reported
All‐cause mortality · children (aged 6 to 11 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Morbidity · children (aged 6 to 11 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Socioeconomic effects · children (aged 6 to 11 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
a) Change in BMI · adolescents (aged 12‐17 years) being overweight or obese
1 finding from 1 review
Intervention not reported
Adverse events · adolescents (aged 12‐17 years) being overweight or obese
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Health‐related quality of life Validated self‐reported measures · adolescents (aged 12‐17 years) being overweight or obese
1 finding from 1 review
Intervention not reported
All‐cause mortality · adolescents (aged 12‐17 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Morbidity · adolescents (aged 12‐17 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Socioeconomic effects · adolescents (aged 12‐17 years) being overweight or obese
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Final diagnosis of at least one episode of AOM · preventing acute otitis media in children up to 12 years of age
Xylitol probably leads to lower final diagnosis of at least one episode of AOM compared with control (moderate certainty).
3 findings from 1 review
RR 0.75 [0.65, 0.88]
3 studies · 1826 participants
Moderate
RR 0.9 [0.67, 1.21]
1 study · 326 participants
Low
RR 1.13 [0.83, 1.53]
1 study · 1253 participants
Moderate
Antibiotic administration ‐ not measured · preventing acute otitis media in children up to 12 years of age
1 finding from 1 review