Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

747 questions · 815 findings · 144 reviews

No studies found 154 · 18.9%GRADE not reported 147 · 18%Very low 164 · 20.1%Low 199 · 24.4%Moderate 121 · 14.8%High 30 · 3.7%

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Performance based measures ‐ Range of motion (possible range 0 (worst) to 140 (maximal) degrees) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis
1 finding from 1 review

Posterior cruciate ligament retention vs sacrifice (using the same arthroplasty design)

Knee pain Knee Society Score, sub score pain (possible range 0 (severe pain) ‐ 50 (no pain) points) · Patients receiving total knee arthroplasty with or without resection of the posterior cruciate ligament for the treatment of osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

High-intensity sweeteners other than stevia (aspartame, sucralose, saccharin) in food products vs Any comparator (dietary sugar, no treatment, or other sweetener)

Effects of non-stevia high-intensity sweeteners (aspartame, sucralose, saccharin) on cariogenic bacteria in dental plaque or saliva · healthy people

No eligible studies evaluated high-intensity sweeteners such as aspartame, sucralose, or saccharin for their effect on cariogenic bacteria.

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs no intervention

Change in Mutans streptococci (MS) count in saliva · healthy people

Xylitol significantly reduced Mutans streptococci in saliva compared with no intervention (SMD -1.47, 95% CI -1.94 to -0.99; 3 trials), though heterogeneity was very high (I2=98%); not GRADE-rated.

1 finding from 1 review

Xylitol (low-intensity sweetener/sugar alcohol) in food products (chewing gum, milk, candy, or tablets) vs Sorbitol (low-intensity sweetener)

Change in Mutans streptococci (MS) count in saliva · healthy people

Xylitol and sorbitol did not differ significantly for Mutans streptococci in saliva (SMD -0.16, 95% CI -0.44 to 0.12; 2 trials, P=.25); not GRADE-rated.

1 finding from 1 review

Xylitol (low-intensity sweetener/sugar alcohol) in food products (chewing gum, milk, candy, or tablets) vs no intervention

Change in Mutans streptococci (MS) count in dental plaque · healthy people

Xylitol significantly reduced Mutans streptococci in dental plaque compared with no treatment (SMD -0.73, 95% CI -1.09 to -0.37; 5 trials, I2=53%; not GRADE-rated).

1 finding from 1 review

Xylitol (low-intensity sweetener/sugar alcohol) in food products (chewing gum, milk, candy, or tablets) vs Sorbitol (low-intensity sweetener)

Change in Mutans streptococci (MS) count in dental plaque · healthy people

Xylitol reduced Mutans streptococci in dental plaque more than sorbitol (SMD -0.45, 95% CI -0.69 to -0.21; 4 trials, I2=7%); not GRADE-rated.

1 finding from 1 review

Dental caries vs Caries-free controls

Oral health-related quality of life · Indians

In adolescents (10-19 years), dental caries was associated with poorer OHRQoL (pooled OR 3.92; 5 studies); ungraded.

5 findings from 1 review
Show 2 more findings

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs Caries-free status

CA VI activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only…

Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated).

1 finding from 1 review

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

Prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse · women with apical uterine prolapse

Vaginal hysterectomy showed no clear difference in prolapse on examination (Stage 2 or greater) ‐ Any recurrent prolapse compared with sacral hysteropexy/cervicopexy (uterine prolapse) (moderate certainty).

1 finding from 1 review

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

Prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse · women with apical uterine prolapse

Vaginal hysteropexy showed no clear difference in prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse compared with sacral hysteropexy (uterine prolapse) (moderate certainty).

1 finding from 1 review