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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Canakinumab vs triamcinolone acetonide Participant global assessment of response to treatment: good or excellent at 72 hours (canakinumab 150 mg) Assessed by the participant on a 5‐point Likert scale (excellent, good, acceptable, slight or poor) · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 1.37 [1.16, 1.61] | 3 studies · 478 participants | Moderate |
Canakinumab vs triamcinolone acetonide Study withdrawals due to AE (all canakinumab doses) · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 1.07 [0.16, 7.23] | 3 studies · 654 participants | Low |
Canakinumab vs triamcinolone acetonide Participants with at least 1 AE (all canakinumab doses) · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | RR 1.2 [1.05, 1.39] | 3 studies · 654 participants | Moderate |
Rilonacept vs indomethacin Pain ‐ change from baseline to 24 to 72 hours Assessed on numerical rating scale (0 = no pain; 10 = extreme pain) · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | 1 study · 148 participants | Low |
Rilonacept vs indomethacin Inflammation ‐ not measured · acute gout Interleukin‐1 inhibitors for acute gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs allopurinol Acute gout attacks · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 3.58 [0.15, 84.13] | 1 study · 55 participants | Low |
Benzbromarone vs probenecid Withdrawal due to adverse events · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 0.15 [0.03, 0.79] | 2 studies · 129 participants | Low |
Benzbromarone vs probenecid Total adverse events · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 0.43 [0.25, 0.74] | 2 studies · 129 participants | Low |
Benzbromarone vs probenecid Pain Reduction ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs probenecid Function ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs probenecid Tophus regression ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Probenecid vs allopurinol Acute gout attacks · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 0.96 [0.53, 1.75] | 1 study · 37 participants | Low |
Probenecid vs allopurinol Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Probenecid vs allopurinol Withdrawal due to adverse events ‐ not reported · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Probenecid vs allopurinol Total adverse events ‐ not reported · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Probenecid vs allopurinol Pain reduction ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs allopurinol Serum urate normalisation · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 1.27 [0.9, 1.79] | 2 studies · 101 participants | Moderate |
Probenecid vs allopurinol Function ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Probenecid vs allopurinol Tophus regression ‐ not reported · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs allopurinol Withdrawal due to adverse events · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 1.25 [0.28, 5.62] | 2 studies · 91 participants | Low |
Benzbromarone vs allopurinol Total adverse events · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 3 [0.64, 14.16] | 1 study · 55 participants | Low |
Benzbromarone vs allopurinol Pain reduction ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs allopurinol Function ‐ not measured · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs allopurinol Tophus regression ‐ not reported · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | no estimate extracted | NR | No studies |
Benzbromarone vs probenecid Acute gout attacks · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 0.73 [0.09, 5.83] | 2 studies · 129 participants | Low |
Benzbromarone vs probenecid Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) · people with chronic gout Uricosuric medications for chronic gout (2014) · Cochrane | RR 1.43 [1.02, 2] | 1 study · 62 participants | Moderate |
Combination of manual therapy and exercise vs glucocorticoid injection Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)g · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 2 studies · 86 participants | Low |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 49 participants | Low |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection Adverse events · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 2 studies · 86 participants | Low |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)f · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 2 studies · 86 participants | Low |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy and exercise vs glucocorticoid injection Overall pain (change from baseline) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 107 participants | Moderate |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 49 participants | Low |
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection Adverse events · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 2 studies · 86 participants | Low |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)f · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 2 studies · 86 participants | Low |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 44 participants | Low |
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection Adverse events · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | NR | No studies |
Combination of manual therapy and exercise vs glucocorticoid injection Function (change from baseline) Shoulder Disabilty Questionnaire 0‐100 (lower scores = better function) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 107 participants | Moderate |
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension Overall pain (change from baseline) · patients with adhesive capsulitis (frozen shoulder) Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane | no estimate extracted | 1 study · 148 participants | High |