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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

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No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Pulmonary exacerbations: rate of PDEs per participant year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: continuous cycles alternating aztreonam lysine… showed no clear difference in pulmonary exacerbations: rate of PDEs per participant year compared with continuous cycles alternating placebo with tobramycin (low certainty).

1 finding from 1 review

Nitrous oxide vs carbon dioxide

Cardiopulmonary complications · people undergoing laparoscopic general abdominal or gynaecological pelvic surgery under general anaesthesia

It is very uncertain whether nitrous oxide changes cardiopulmonary complications compared with carbon dioxide (very low certainty).

1 finding from 1 review

Laser therapy vs no treatment

Scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus no treatment ‐ patient self‐assessment of scar improvement of 50% or higher ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars

Laser therapy may leads to higher scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus no treatment ‐… compared with no treatment (low certainty).

1 finding from 1 review

Laser therapy plus other treatment vs other treatment

Scar severity ‐ 585‐nm pulsed‐dye laser (PDL) plus triamcinolone acetonide (TAC) plus 5‐Fluorouracil (5‐FU) versus TAC plus 5‐FU ‐ blinded observer assessment of good to excellent scar improvement ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars

It is very uncertain whether laser therapy plus other treatment changes scar severity ‐ 585‐nm pulsed‐dye laser (PDL) plus triamcinolone… compared with other treatment (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Preoperative exercise training vs no exercise

Number of patients who developed postoperative pulmonary complications · people scheduled to undergo lung resection for non‐small cell lung cancer

Summary of findings table ‐ Preoperative exercise training leads to lower risk of developing a postoperative pulmonary complication – total compared with no exercise training (high certainty).

1 finding from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in hospitalisation for pulmonary exacerbations compared with 28 days on/off placebo regimen (high certainty).

1 finding from 1 review