What do systematic reviews say?

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.2 [0.01, 4.08]
  2 studies · 136 participants
  Low

Extra-oral pulp extirpation at day 0 vs Intra-oral pulp extirpation at day 7

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
  Giannetti 2006 did not report this outcome; following email correspondence, authors reported no adverse effects were seen (uncertain whether formally assessed).
  1 study
  GRADE not reported

Dextrose gel vs oral (swallowed) glucose

It is very uncertain whether oral + buccal glucose (dextrose gel) changes resolution of symptoms within 20 minutes compared with oral (swallowed) glucose (very low certainty).

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  RR 0.36 [0.12, 1.14]
  1 study · 18 participants
  Very low

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Extra-oral pulp extirpation at day 0 vs Intra-oral pulp extirpation at day 7

It is very uncertain whether extra-oral pulp extirpation at day 0 changes radiographic resorption (proxy measure for periodontal healing) at… compared with intra-oral pulp extirpation at day 7 (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  RR 1.35 [0.81, 2.24]
  1 study · 19 participants
  Very low

Dextrose gel vs control

Oral dextrose gel showed no clear difference in correction of hypoglycaemia for each hypoglycaemic event before… compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  Rate ratio 1.08 [0.98, 1.2]
  1 study · 237 participants
  Moderate

Dextrose gel vs control

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.46 [0.09, 2.47]
  1 study · 185 participants
  Low

Dextrose gel vs control

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.78 [0.46, 1.32]
  2 studies · 312 participants
  Very low

Dextrose gel vs control

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 237 participants
  Low

Dextrose gel vs control

Oral dextrose gel probably leads to lower separation from mother for treatment of hypoglycaemia before… compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.54 [0.31, 0.93]
  1 study · 237 participants
  Moderate

Dextrose gel vs control

Oral dextrose gel probably leads to higher exclusive breastfeeding after discharge (WHO 2008 definition (yes/no)) compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 1.1 [1.01, 1.18]
  1 study · 237 participants
  Moderate

FLUPHENAZINE (ORAL) vs placebo

It is very uncertain whether ORAL FLUPHENAZINE changes global state: Not improved or worsened ‐ medium termDichotomised… compared with PLACEBO (very low certainty).

• Fluphenazine (oral) versus placebo for schizophrenia 2018 · Cochrane Headline outcomes only
  RR 1.12 [0.79, 1.58]
  1 study · 50 participants
  Very low

FLUPHENAZINE (ORAL) vs placebo

It is very uncertain whether ORAL FLUPHENAZINE changes global state: Relapse ‐ long termClinical judgement compared with PLACEBO (very low certainty).

• Fluphenazine (oral) versus placebo for schizophrenia 2018 · Cochrane Headline outcomes only
  RR 0.39 [0.05, 3.31]
  2 studies · 86 participants
  Very low

FLUPHENAZINE (ORAL) vs placebo

ORAL FLUPHENAZINE showed no clear difference in adverse effects: Death ‐ long termOccurrences of death compared with PLACEBO (low certainty).

• Fluphenazine (oral) versus placebo for schizophrenia 2018 · Cochrane Headline outcomes only
  RR 2.38 [0.1, 55.72]
  1 study · 50 participants
  Low

FLUPHENAZINE (ORAL) vs placebo

ORAL FLUPHENAZINE probably leads to higher adverse effects: Extrapyramidal effects (akathisia) ‐ short… compared with PLACEBO (moderate certainty).

• Fluphenazine (oral) versus placebo for schizophrenia 2018 · Cochrane Headline outcomes only
  RR 3.43 [1.23, 9.56]
  2 studies · 227 participants
  Moderate