Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Hydroxychloroquine (HCQ) vs placebo or usual care

Participants with prolongation of QT‐interval on ECG · adults with mild to severe COVID‐19

It is very uncertain whether hydroxychloroquine (HCQ) changes participants with prolongation of QT‐interval on ECG compared with standard care or placebo (very low certainty).

1 finding from 1 review

Traditional suburethral sling operation vs open abdominal retropubic suspension

Long‐term adverse effects Number of women with recurrent UTIs at > 5 years · women with urinary incontinence

Traditional suburethral sling operation showed no clear difference in long‐term adverse effects Number of women with recurrent UTIs at > 5… compared with open abdominal retropubic colposuspension (low certainty).

1 finding from 1 review

Traditional suburethral sling operation vs a mid‐urethral sling or tape

Long‐term adverse effects Release of sling required · women with urinary incontinence

It is very uncertain whether traditional suburethral sling operation changes long‐term adverse effects Release of sling required compared with a mid‐urethral sling or tape (very low certainty).

1 finding from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Clinical cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral showed no clear difference in clinical cure (long term; 2 to 12 weeks) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

1 finding from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Mycological cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral probably leads to higher mycological cure (long term; 2 to 12 weeks) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

1 finding from 1 review