Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

920 questions · 964 findings · 153 reviews

No studies found 215 · 22.3%GRADE not reported 85 · 8.8%Very low 241 · 25%Low 260 · 27%Moderate 135 · 14%High 28 · 2.9%

NIPPV vs NCPAP

Gastrointestinal perforation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in gastrointestinal perforation compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Necrotising enterocolitis · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in necrotising enterocolitis compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Chronic lung disease · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in chronic lung disease (oxygen supplementation at 36 weeks) compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Mortality before hospital discharge · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in mortality (defined as death before discharge) compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Need for endotracheal tube ventilation · )

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower need for endotracheal tube ventilation compared with nasal continuous positive airway pressure (NCPAP) (by population) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · )

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in severe intraventricular hemorrhage (grade III/IV) compared with nasal continuous positive airway pressure (NCPAP) (by population) (low certainty).

1 finding from 1 review

Intermittent phototherapy vs continuous phototherapy

Bilirubin‐induced brain dysfunction (defined as either the pathological finding of deep‐yellow staining of neurons and neuronal necrosis of the basal ganglia and brainstem nuclei or acute or chronic neurological deficit including athetoid cerebral... · neonatal jaundice
1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Treatment failure · preterm infants receiving nasal CPAP

Bubble may leads to lower treatment failure compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Mortality before hospital discharge · preterm infants receiving nasal CPAP

Bubble showed no clear difference in all‐cause mortality before hospital discharge compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Pneumothorax · preterm infants receiving nasal CPAP

Bubble showed no clear difference in pneumothorax compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Moderate‐severe nasal injury · preterm infants receiving nasal CPAP

Bubble probably leads to higher moderate‐severe nasal injury compared with ventilator or Infant Flow Driver nasal continuous positive airway… (moderate certainty).

1 finding from 1 review