Postoperative pain (VAS) · Mature permanent (molar) teeth with deep caries and symptoms indicative of irreversible pulpitis (spontaneous pain)
Postoperative pain was similar between partial and full pulpotomy in one RCT but significantly greater after partial pulpotomy in the other (ungraded).
1 finding from 1 review
Jassal: no significant difference in postoperative pain between PP and FP at 24 h, 48 h and 7 days (preoperative PP 7.44+/-0.96 vs FP 7.52+/-1.08, p>.879). Ramani: no difference in pain incidence at 24 h (p=.496) but…
2 studies · 156 participants
GRADE not reported
Haemoglobin (g/dL) · Children or adolescents
Haemoglobin tends to be lower in children with dental caries, but the pooled difference is not statistically significant (MD -2.20 g/dL, 95% CI -4.59 to 0.19; very low certainty).
1 finding from 1 review
Intervention not reported
Sensitivity
1 finding from 1 review
Relative abundance of Veillonella spp. · Individuals assessed for dental caries, predominantly children with early childhood caries (ECC) or severe ECC (age about 1 to 4 years)
Evidence on whether Veillonella spp. relative abundance is higher or lower in children with dental caries than caries-free controls is inconsistent across 7 small observational studies; no pooled estimate was produced and the evidence is ungraded.
1 finding from 1 review
Plaque · Individuals assessed for periodontal health (mainly children and adolescents, age >2 years)
Persons with orofacial cleft have a higher plaque index than healthy controls (MD 0.29, 95% CI 0.24 to 0.34; low certainty).
1 finding from 1 review
Intervention not reported
Inhibition of mixed-species S. mutans-C. albicans biofilm and C. albicans virulence-gene (HWP1/ALS1/ALS3) downregulation
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Intervention not reported
Composite: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention led to higher composite: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 1.95 [1.50, 2.54]
Studies not reported
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Control showed no significant difference in 24 h bond strength (MD 1.539, 95% CI -1.738 to 4.817; Moderate certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure
Partial pulpotomy with tri-calcium silicate cements (MTA/Biodentine) has a much higher success rate than with calcium hydroxide in adults (86.8% vs 34.3%; ungraded).
2 findings from 1 review
Proper surface staining · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)
No significant difference between IRR and CR in surface staining (moderate certainty; downgraded for inconsistency).
1 finding from 1 review
Salivary alpha-amylase · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
There is no significant difference in salivary alpha-amylase between anorexia nervosa patients and healthy controls (MD 6.32 U/l, 95% CI -6.14 to 18.79; low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Adults (>=18 y) with mature permanent teeth and deep carious pulp exposure
Immediate permanent restoration after partial pulpotomy is associated with much higher success than delayed restoration (89.9% immediate vs 23.2% beyond 14 days; ungraded).
1 finding from 1 review
Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, SDF had significantly higher treatment success than placebo (OR 33.62).
1 finding from 1 review
OR 33.62 [3.01, 375.92]
44 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 7:…; GRADE not reported.
1 finding from 1 review
RR 22.43 [12.83, 39.24]
7 studies
GRADE not reported
Salivary flow rate (unstimulated) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa probably reduces unstimulated salivary flow rate versus healthy controls (MD -0.27 ml/min, 95% CI -0.31 to -0.24; moderate certainty).
1 finding from 1 review
Intervention not reported
Brushing independence and skill retention
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Mature permanent (molar) teeth with deep caries and symptoms indicative of irreversible pulpitis (spontaneous pain)
Within two high-quality RCTs, partial and full pulpotomy achieved similar 1-year clinical/radiographic success for irreversible pulpitis (pooled 83% vs 90%), with no significant difference (high certainty).
1 finding from 1 review
FP 90%, PP 83% (pooled unadjusted 1-year success; no significant difference; no meta-analysis)
2 studies · 135 participants
High
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Fluorine showed no significant difference in 24 h bond strength (MD 2.500, 95% CI -2.603 to 7.603; Low certainty).
1 finding from 1 review
Negative likelihood ratio · Patients undergoing dental caries detection on dental images (teeth/surfaces across imaging modalities)
A negative AI test lowers caries probability substantially (LR- 0.17; negative post-test probability 6%); ungraded.
1 finding from 1 review