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What do systematic reviews say?

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Evidence found and GRADE certainty

1,166 questions · 1,249 findings · 76 reviews

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No studies found 378 · 30.3%GRADE not reported 61 · 4.9%Very low 377 · 30.2%Low 284 · 22.7%Moderate 120 · 9.6%High 29 · 2.3%

Antibiotics vs placebo or no intervention

All‐cause mortality · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in all‐cause mortality compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Laboratory‐confirmed leptospirosis · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes laboratory‐confirmed leptospirosis compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis of infection regardless of laboratory confirmed · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis of infection regardless of laboratory confirmed compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis confirmed by laboratory diagnosis · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis confirmed by laboratory diagnosis compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Non‐serious adverse events · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

All‐cause mortality · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Adverse events considered non‐serious · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Glutamine vs placebo

Incidence of hepatic veno‐occlusive disease ( · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes incidence of hepatic veno‐occlusive disease ( compared with placebo (very low certainty).

1 finding from 1 review

Glutamine vs placebo

All‐cause mortality at 100 days post‐transplant · People undergoing stem cell transplant with haematological malignancies

It is very uncertain whether summary of findings: Glutamine changes all‐cause mortality at 100 days post‐transplant ( compared with placebo (very low certainty).

1 finding from 1 review