Findings

What do systematic reviews say?

529 questions · 535 findings · 63 reviews · Airways

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No studies found 41 · 7.7%GRADE not reported 28 · 5.2%Very low 35 · 6.5%Low 151 · 28.2%Moderate 204 · 38.1%High 76 · 14.2%

Inhaled corticosteroids vs placebo

FEV1 (L) · patients with acute asthma

ICS showed no clear difference in FEV1 at 1 hour compared with placebo (low certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
MD 0.28
4 studies · 248 participants
Low

Inhaled corticosteroids vs placebo

FEV1 · patients with acute asthma

ICS showed no clear difference in FEV1 at 3 to 4 hours compared with placebo (moderate certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
MD 0.15
4 studies · 319 participants
Moderate

Inhaled corticosteroids vs placebo

Nausea and vomiting · patients with acute asthma

ICS showed no clear difference in adverse effects ‐ nausea/vomiting compared with placebo (low certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
OR 0.32 [0.03, 3.18]
1 study · 94 participants
Low

Any ICS plus oral corticosteroid vs oral corticosteroid

Asthma relapse1at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in asthma relapse1at 20 to 24 days compared with oral corticosteroid (high certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 0.68 [0.46, 1.02]
3 studies · 909 participants
High

Any ICS plus oral corticosteroid vs oral corticosteroid

Hospital admissions · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hospital admission compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 0.99 [0.39, 2.52]
2 studies · 805 participants
Moderate

Any ICS plus oral corticosteroid vs oral corticosteroid

Hoarseness at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hoarseness at 20 to 24 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 0.6 [0.36, 1.01]
2 studies · 596 participants
Moderate

Any ICS vs oral corticosteroid

Asthma relapse1at 16 to 21 days · patients with acute asthma following emergency department discharge

Any ICS showed no clear difference in asthma relapse1at 16 to 21 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 1.26 [0.8, 1.99]
2 studies · 425 participants
Moderate

Any ICS vs oral corticosteroid

Hospital admissions · patients with acute asthma following emergency department discharge

Any ICS showed no clear difference in hospital admission compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 0.31 [0.01, 7.95]
3 studies · 254 participants
Moderate

Any ICS vs oral corticosteroid

Hoarseness at 16 to 21 days · patients with acute asthma following emergency department discharge

Any ICS showed no clear difference in hoarseness at 16 to 21 days compared with oral corticosteroid (low certainty).

1 finding from 1 review

Inhaled steroids for acute asthma following emergency department discharge 2012 · Cochrane Headline outcomes only
OR 1.62 [0.52, 5.05]
1 study · 412 participants
Low