MMP-8 location/presence · Human carious dentin
Evidence on MMP-8 by lesion depth or location was very low certainty.
1 finding from 1 review
MMP-20 expression · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-20 expression was found between irradiated and non-irradiated carious dentin (very low certainty).
1 finding from 1 review
MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-2 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low
Cathepsin B (CT-B) presence/activity · Human coronal carious dentin and sound dentin
Cathepsin B may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
MMP-20 expression · Human carious dentin
MMP-20 probably reduces in outer compared with inner carious dentin (moderate certainty).
1 finding from 1 review
no estimate extracted
1 study · 5 participants
Moderate
Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).
1 finding from 1 review
Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomesOral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported
Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa
The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.
2 findings from 1 review
Prevalence 0.3657 [0.3065, 0.4250]
Studies not reported
GRADE not reported
Prevalence 0.356 [0.294, 0.417]
Studies not reported
GRADE not reported
Intervention not reported
Caries prevalence
1 finding from 1 review
Fever · Residents of nursing homes and other long-term care facilities
Professional oral care led to lower incidence or prevalence of fever compared with usual oral care; GRADE not reported.
1 finding from 1 review
Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Intensive periodontal treatment (subgingival SRP with or without… probably leads to lower change in diastolic blood pressure (DBP, mmHg) compared with supra-gingival scaling (moderate certainty).
3 findings from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in diastolic blood pressure (DBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).
4 findings from 1 review
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Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence in permanent dentition (>=12 years) was 50.2% (95% CI 38.4 to 62.1); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
The pooled prevalence of dental caries in East Africa (2000-2020) was 45.7% (95% CI 38.0 to 53.4); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Systolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in systolic blood pressure (SBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).
4 findings from 1 review
Show 1 more finding
Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)
Fixed-effect pooled dental caries prevalence was 57.0% (95% CI 56.4% to 57.6%).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence was highest in Eritrea at 65.2% (95% CI 49.2 to 81.1); certainty not graded.
1 finding from 1 review