What do systematic reviews say?

Use of rescue medication · adults with episodic tension‐type headache

Any adverse event · adults with episodic tension‐type headache

Specific adverse events · adults with episodic tension‐type headache

Serious adverse events · adults with episodic tension‐type headache

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain

Lack of efficacy withdrawal · adults with chronic neuropathic pain

Withdrawals due to adverse events · adults with chronic neuropathic pain

Serious adverse events · adults with chronic neuropathic pain

Deaths · adults with chronic neuropathic pain

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia

Lack of efficacy withdrawal · adults with fibromyalgia

Withdrawals due to adverse events · adults with fibromyalgia

Serious adverse events · adults with fibromyalgia