What do systematic reviews say?

Regional anaesthesia vs conventional pain control

• Regional analgesia for improvement of long‐term functional outcome after elective large joint replacement 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 140 participants
  Very low

Ruxolitinib vs placebo

Ruxolitinib may leads to higher health‐related quality of life Patients that achieved a reduction of… compared with placebo (low certainty).

• Janus kinase‐1 and Janus kinase‐2 inhibitors for treating myelofibrosis 2015 · Cochrane Headline outcomes only
  RR 8.82 [4.4, 17.69]
  1 study · 309 participants
  Low

Flutamide 250 mg b.i.d. vs placebo

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 60 participants
  Very low

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 40 participants
  Very low

Spironolactone 100 mg vs placebo

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Finasteride 5 mg to 7.5 mg vs placebo

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 62 participants
  Very low

Metformin 500 mg to 2550 mg per day vs placebo

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 264 participants
  Low

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 164 participants
  Low

Finasteride 5 mg vs spironolactone 100 mg

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 34 participants
  Low

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 95 participants
  Very low

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 226 participants
  Very low

Intervention not reported

The intervention leads to lower CRBSI (confirmed) Clinical and microbiological assessments (high certainty).

• Antibiotic lock for the prevention of catheter‐related infection in neonates 2015 · Cochrane Headline outcomes only
  RR 0.15 [0.06, 0.4]
  3 studies · 271 participants
  High

Intervention not reported

The intervention showed no clear difference in CRBSI (suspected) Clinical assessment (moderate certainty).

• Antibiotic lock for the prevention of catheter‐related infection in neonates 2015 · Cochrane Headline outcomes only
  RR 0.65 [0.22, 1.92]
  3 studies · 271 participants
  Moderate

Intervention not reported

The intervention leads to lower total CRBSI (confirmed and suspected) Clinical and microbiological… (high certainty).

• Antibiotic lock for the prevention of catheter‐related infection in neonates 2015 · Cochrane Headline outcomes only
  RR 0.25 [0.12, 0.49]
  3 studies · 271 participants
  High

Intervention not reported

It is very uncertain whether the intervention changes mortality Clinical assessment (very low certainty).

• Antibiotic lock for the prevention of catheter‐related infection in neonates 2015 · Cochrane Headline outcomes only
  RR 0.12 [0.01, 2.13]
  1 study · 103 participants
  Very low

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

The review found no eligible studies for this question.

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Parent‐infant psychotherapy vs control

• Parent‐infant psychotherapy for improving parental and infant mental health 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 356 participants
  Low

Parent‐infant psychotherapy vs other (psychoeducational) parenting intervention: parent mental health and infant attachment

• Parent‐infant psychotherapy for improving parental and infant mental health 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 172 participants
  Very low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Bilateral subtotal thyroidectomy showed no clear difference in regression of Graves' ophthalmopathy [ophthalmology assessment] compared with the Dunhill procedure (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 0.78 [0.32, 1.92]
  2 studies · 90 participants
  Low

Total thyroidectomy vs subtotal thyroidectomy

Total thyroidectomy showed no clear difference in regression of Graves' ophthalmopathy [ophthalmology assessment] compared with subtotal thyroidectomy (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.15 [0.64, 2.08]
  2 studies · 229 participants
  Low
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.19 [0.64, 2.21]
  2 studies · 260 participants
  Low