Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

948 questions · 998 findings · 100 reviews · Headline outcomes only

No studies found 233 · 23.3%GRADE not reported 40 · 4%Very low 203 · 20.3%Low 271 · 27.2%Moderate 176 · 17.6%High 75 · 7.5%

Vitamin D plus calcium vs placebo or control

Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

New fractures · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Apixaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Rivaroxaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Dabigatran (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review