Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,192 questions · 1,243 findings · 151 reviews

No studies found 252 · 20.3%GRADE not reported 180 · 14.5%Very low 291 · 23.4%Low 282 · 22.7%Moderate 174 · 14%High 64 · 5.1%

Combination chemotherapy vs single‐agent chemotherapy

Metastases intra‐abdominal · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy showed no clear difference in metastases intra‐abdominal compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Radiotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy probably leads to lower radiotherapy compliance compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Chemotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy leads to lower chemotherapy compliance compared with single‐agent chemotherapy (high certainty).

1 finding from 1 review

Arthroplasty vs fusion

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with single‐level cervical degenerative disc disease
2 findings from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke
2 findings from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review