Combination chemotherapy vs single‐agent chemotherapy: Chemotherapy compliance
Combination chemotherapy leads to lower chemotherapy compliance compared with single‐agent chemotherapy (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combination chemotherapy vs single‐agent chemotherapy Chemotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery Combination chemotherapy leads to lower chemotherapy compliance compared with single‐agent chemotherapy (high certainty). Combination chemotherapy versus single‐agent chemotherapy during preoperative chemoradiation for resectable… (2015) · Cochrane Headline outcomes only | OR 0.36 [0.26, 0.52] | 2 studies · 1331 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Combination chemotherapy versus single‐agent chemotherapy during preoperative chemoradiation for resectable rectal cancer 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.