Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

584 questions · 593 findings · 51 reviews · Airways

No studies found 37 · 6.2%GRADE not reported 40 · 6.7%Very low 44 · 7.4%Low 172 · 29%Moderate 232 · 39.1%High 68 · 11.5%

Intervention not reported

Mortality, due to pneumonia · patients with chronic obstructive pulmonary disease

It is very uncertain whether the intervention changes mortality, due to pneumonia (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse events (all) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse events (all) (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention leads to higher non‐fatal, serious adverse pneumonia events (requiring hospital… (high certainty).

1 finding from 1 review

Intervention not reported

Mortality, due to pneumonia · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in mortality, due to pneumonia (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse events (all) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse events (all) (high certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse pneumonia events (requiring hospital… (moderate certainty).

1 finding from 1 review

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

Asthma clinical scores · children hospitalised with an acute asthma exacerbation

Combination of anticholinergics + beta2‐agonists showed no clear difference in asthma clinical scores compared with beta2‐agonists alone (moderate certainty).

1 finding from 1 review