Cochrane · systematic review · CD009878
Inhaled corticosteroids in children with persistent asthma: dose‐response effects on growth
Pruteanu, AI, Chauhan, BF, Zhang, L, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled corticosteroids dose‐response effect
Population: children with persistent asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Growth velocity over 12 months (cm/y) (higher is better) | MD 0.2 [0.02, 0.39] | 4 studies · 728 participants | High |
Change in height over 3 months (cm) (higher is better) | no estimate extracted | 9 studies · 944 participants | Moderate |
Change in height over 12 months (cm) (higher is better) | MD 0.25 | 4 studies · 548 participants | Moderate |
Change in SD scores over 12 months (height) (low change is better) | MD 0.08 | 3 studies · 328 participants | Moderate |
Change in weight over 12 months (kg) (higher is better) | no estimate extracted | 1 study · 408 participants | Low |
Change in BMI over 12 months (kg/m2) (higher is better) | no estimate extracted | 1 study · 408 participants | Low |
Change in skeletal maturation over 12 months (years) (higher is better) | MD 0.18 [0.02, 0.34] | 1 study · 181 participants | Low |