Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,372 questions · 3,874 findings · 666 reviews

No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

High dose clonidine vs low dose clonidine

Number requiring additional analgesia required postoperatively ‐ moderate quality studies · patients with postoperative pain

High dose clonidine may leads to lower number requiring additional analgesia required postoperatively ‐… compared with low dose clonidine (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Proportion with 50% or greater decrease in inflammation score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher reduction of inflammation: proportion with 50% or greater decrease… compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Total adverse events · acute gout

High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH

Subcutaneous bruises · people with antiphospholipid antibodies and no history of thrombosis

ASA + high‐dose LMWH showed no clear difference in subcutaneous bruises compared with ASA + low‐dose LMWH or UFH (low certainty).

1 finding from 1 review

High intake of sweets vs Lower/less intake of sweets

Dental caries · Primary school children in Ethiopia

A high intake of sweets was associated with higher odds of dental caries (OR 2.71, 95% CI 1.968-3.451; ungraded).

1 finding from 1 review

Higher dose vitamin K vs lower dose vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review