Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,005 questions · 1,053 findings · 151 reviews · Headline outcomes only

No studies found 275 · 26.1%GRADE not reported 150 · 14.2%Very low 271 · 25.7%Low 215 · 20.4%Moderate 105 · 10%High 37 · 3.5%

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

Dropouts ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (SSRI) with ziprasidone (40… probably leads to higher dropouts ‐ Any dose compared with augmentation of current antidepressant (SSRI) with placebo or… (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

Response (≥ 50% reduction in MADRS or HAM‐D score) ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (SSRI) with ziprasidone (40… probably leads to higher response (≥ 50% reduction in MADRS/HAM‐D score) ‐ Any dose compared with augmentation of current antidepressant (SSRI) with placebo or… (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

Remission · treatment‐resistant depression in adults

Augmentation of current antidepressant (SSRI) with ziprasidone (40… showed no clear difference in remission (clinician‐rated) ‐ Any dose compared with augmentation of current antidepressant (SSRI) with placebo or… (moderate certainty).

1 finding from 1 review

Therapeutic community and aftercare vs cognitive behavioural skills

Criminal activity ‐ Re‐arrests · drug‐using women offenders with co‐occurring mental health problems

Therapeutic community and aftercare showed no clear difference in re‐arrest for any type of crime compared with cognitive behavioural skills (low certainty).

1 finding from 1 review

Cognitive behavioural therapy and other therapies vs prison therapeutic community

Arrested for any crime at 6 months · summary findings of female review

It is very uncertain whether cognitive behavioural therapy and other therapies changes arrested for any crime at 6 months compared with prison therapeutic community (very low certainty).

1 finding from 1 review

Intervention not reported

Any upper gastrointestinal bleeding in infants at risk of upper gastrointestinal bleeding · newborn infants at risk of gastrointestinal bleeding

The intervention probably leads to lower any upper gastrointestinal bleeding in infants at risk of upper… (moderate certainty).

1 finding from 1 review

Multiple methods of breastfeeding support (including social, educational and/or physical support) vs usual care

Breastfeeding · pregnant or lactating women who were overweight or obese

It is very uncertain whether multiple methods of breastfeeding support (including social,… changes any breastfeeding at 6 months compared with usual care (very low certainty).

2 findings from 1 review

Barrier creams vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Barrier creams and moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams and moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review