Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

627 questions · 638 findings · 45 reviews

No studies found 89 · 13.9%GRADE not reported 37 · 5.8%Very low 221 · 34.6%Low 181 · 28.4%Moderate 92 · 14.4%High 18 · 2.8%

Antidepressants vs placebo

Number of responders · patients with depression and dementia

Antidepressant treatment showed no clear difference in number of responders (ITT) at 6 to 12 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Risk for at least one adverse event per patient · patients with depression and dementia

Antidepressant treatment probably leads to higher number of patients experiencing at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Postnatal depression (17 weeks) · women with a history of postnatal depression

It is very uncertain whether the intervention changes postnatal depression (17 weeks) (very low certainty).

1 finding from 1 review

Intervention not reported

Overall maternal satisfaction (17 weeks) · women with a history of postnatal depression

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Improvement in the maternal relationship with the baby (17 weeks) · women with a history of postnatal depression

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Establishment or continuation of breastfeeding (17 weeks) · women with a history of postnatal depression

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects experienced by mother and/or foetus or nursing baby · women with a history of postnatal depression
1 finding from 1 review