Findings

What do systematic reviews say?

2,123 questions · 2,188 findings · 243 reviews

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No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Topical antibiotics vs placebo/no treatment

Ear pain (otalgia) or discomfort or local irritation · patients with mucopurulent otorrhoea

1 finding from 1 review

Topical antibiotics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Topical antibiotics vs placebo/no treatment

Hearing · patients with mucopurulent otorrhoea

1 finding from 1 review

Topical antibiotics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Topical antibiotics vs placebo/no treatment

Serious complications · patients with mucopurulent otorrhoea

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs placebo/no treatment

Suspected ototoxicity · patients with mucopurulent otorrhoea

1 finding from 1 review

Topical antibiotics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Topical antibiotics vs acetic acid

Resolution of ear discharge ‐ measured at 1 to 2 weeks · chronic suppurative otitis media

It is very uncertain whether topical antibiotics changes resolution of ear discharge (1 to 2 weeks) Aminoglycosides compared with acetic acid (very low certainty).

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
RR 0.88 [0.72, 1.08]
1 study · 100 participants
Very low

Topical antibiotics vs acetic acid

Resolution of ear discharge ‐ measured after 4 weeks · chronic suppurative otitis media

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs acetic acid

Quality of life ‐ not measured · chronic suppurative otitis media

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs acetic acid

Ear pain (otalgia) or discomfort or local irritation · chronic suppurative otitis media

It is very uncertain whether topical antibiotics changes ear pain, discomfort, irritation compared with acetic acid (very low certainty).

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
RR 0.16 [0.02, 1.34]
2 studies · 189 participants
Very low

Topical antibiotics vs acetic acid

Hearing · chronic suppurative otitis media

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 107 participants
Very low

Topical antibiotics vs acetic acid

Serious complications ‐ not measured · chronic suppurative otitis media

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs acetic acid

Suspected ototoxicity · chronic suppurative otitis media

It is very uncertain whether topical antibiotics changes suspected ototoxicity compared with acetic acid (very low certainty).

1 finding from 1 review

Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

Topical antibiotics vs antiseptic agent

Number of wounds healed · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs antiseptic agent

Surgical site infection · people presenting for surgery where healing of surgical wound planned to be by primary intention

Topical antibiotics probably leads to lower surgical site infection compared with antiseptic (moderate certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 0.49 [0.3, 0.8]
4 studies · 1299 participants
Moderate

Topical antibiotics vs antiseptic agent

Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention

It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with antiseptic (very low certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 0.97 [0.52, 1.82]
1 study · 541 participants
Very low

Topical antibiotics vs antiseptic agent

Adverse event: anaphylaxis · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Death · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Adverse effects · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Cure: successful eradication of the infection · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics alone changes cure: successful eradication of the infection compared with systematic antibiotics plus antibiotic lock solution (very low certainty).

1 finding from 1 review

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
RR 1.61 [1.16, 2.23]
1 study · 64 participants
Very low

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Stenosis or thrombosis of vascular access site after catheter removal · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Treatment with antibiotics vs No antibiotics, placebo, or different types of antibiotics

Outcome not reported · People with avulsed and replanted permanent (front) teeth

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found