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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,751 questions in 147 reviews · Pain, Palliative and Supportive Care
current versionsNo studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Para/propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.79 [0.66, 0.95] | 5 studies · 355 participants | Very low |
Intervention NR Paracetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.82 [0.66, 1.02] | 3 studies · 212 participants | Very low |
Intervention NR Propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.75 [0.56, 1.02] | 2 studies · 143 participants | Very low |
Intervention NR Paracetamol vs propacetamol see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.94 [0.73, 1.2] | 3 studies · 361 participants | Low |
Intervention NR Paracetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 6 studies · 485 participants | Low |
Intervention NR Paracetamol vs NSAIDs · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 6 studies · 350 participants | Very low |
Intervention NR Paracetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 12 studies · 837 participants | Low |
Intervention NR Paracetamol vs NSAIDs · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 9 studies · 524 participants | Very low |
Intervention NR Para/propacetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.7 [0.64, 0.77] | 9 studies · 859 participants | Low |
Intervention NR Paracetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 4.8 [2.3, 10] | 5 studies · 393 participants | Moderate |
Intervention NR Paracetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.75 [0.69, 0.82] | 6 studies · 655 participants | Low |
Intervention NR Propacetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.49 [0.35, 0.69] | 3 studies · 204 participants | Low |
Intervention NR Para/propacetamol vs NSAIDs · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.19 [0.87, 1.63] | 5 studies · 309 participants | Very low |
Intervention NR Paracetamol vs NSAIDs · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.08 [0.59, 1.98] | 2 studies · 120 participants | Very low |
Intervention NR Propacetamol vs NSAIDs · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.23 [0.86, 1.77] | 3 studies · 189 participants | Very low |
Intervention NR Propacetamol vs opioids · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.83 [0.72, 4.64] | 2 studies · 139 participants | Very low |
Intervention NR Para/propacetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 13 studies · 777 participants | Moderate |
Intervention NR Paracetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 8 studies · 404 participants | Low |
Intervention NR Propacetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 6 studies · 373 participants | Low |
Intervention NR Para/propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 8 studies · 540 participants | Very low |
Intervention NR Propacetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 2.19 [1.74, 2.77] | 8 studies · 756 participants | Moderate |
Intervention NR Paracetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 3 studies · 160 participants | Very low |
Intervention NR Propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | no estimate extracted | 5 studies · 380 participants | Very low |
Intervention NR Para/propacetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.7 [0.57, 0.87] | 15 studies · 1414 participants | Very low |
Intervention NR Paracetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.64 [0.51, 0.8] | 13 studies · 1037 participants | Very low |
Intervention NR Propacetamol vs placebo · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.62 [0.75, 3.48] | 3 studies · 377 participants | Low |
Intervention NR Para/propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.01 [0.86, 1.18] | 5 studies · 353 participants | Low |
Intervention NR Paracetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.9 [0.72, 1.13] | 2 studies · 130 participants | Very low |
Intervention NR Propacetamol vs NSAIDs see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 1.08 [0.86, 1.34] | 3 studies · 223 participants | Very low |
Intervention NR Paracetamol vs propacetamol see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 0.98 [0.77, 1.24] | 3 studies · 361 participants | Moderate |
Intervention NR Para/propacetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 2.86 [2.1, 3.91] | 10 studies · 1143 participants | Moderate |
Intervention NR Paracetamol vs placebo see footnote1 · patients with postoperative pain Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain (2016) · Cochrane | RR 3.65 [2.15, 6.21] | 6 studies · 532 participants | Moderate |
Intervention NR Topical diclofenac gel or solution Clinical success (for example 50% reduction in pain) · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | 6 studies · 2342 participants | Moderate |
Intervention NR Topical ketoprofen gel Clinical success (for example 50% reduction in pain) · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | 4 studies · 2573 participants | Moderate |
Intervention NR Topical diclofenac gel or solution Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | 15 studies · 3658 participants | Moderate |
Intervention NR Topical ketoprofen gel Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | 4 studies · 2621 participants | Moderate |
Intervention NR Systemic adverse events · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Serious adverse events · adults with chronic musculoskeletal pain (osteoarthritis) Topical NSAIDs for chronic musculoskeletal pain in adults (2016) · Cochrane | no estimate extracted | 30 participants | Very low |
Educational interventions vs control (usual care or attention control) General fatigue (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | no estimate extracted | 12 studies · 1711 participants | Low |
Educational interventions vs control (usual care or attention control) Fatigue intensity (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | no estimate extracted | 8 studies · 1524 participants | Moderate |
Educational interventions vs control (usual care or attention control) Fatigue distress (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | no estimate extracted | 3 studies · 622 participants | Low |
Educational interventions vs control (usual care or attention control) Fatigue interference (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | SMD 0.35 | 4 studies · 439 participants | Moderate |
Educational interventions vs control (usual care or attention control) Anxiety (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | no estimate extracted | 3 studies · 571 participants | Low |
Educational interventions vs control (usual care or attention control) Depression (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | no estimate extracted | 4 studies · 881 participants | Very low |
Educational interventions vs control (usual care or attention control) Global quality of life (at the end of the educational intervention) · patients with cancer‐related fatigue (adults) Educational interventions for the management of cancer‐related fatigue in adults (2016) · Cochrane | MD 11.47 | 2 studies · 477 participants | Low |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Pain‐free response at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | High |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Pain‐free response at 2 h for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | High |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Headache relief at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | High |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | Moderate |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Sustained pain‐free during the 24 h post dose for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | High |