Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

529 questions · 535 findings · 63 reviews · Airways

No studies found 41 · 7.7%GRADE not reported 28 · 5.2%Very low 35 · 6.5%Low 151 · 28.2%Moderate 204 · 38.1%High 76 · 14.2%

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention leads to higher non‐fatal, serious adverse pneumonia events (requiring hospital… (high certainty).

1 finding from 1 review

Intervention not reported

Mortality, due to pneumonia · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in mortality, due to pneumonia (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse events (all) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse events (all) (high certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse pneumonia events (requiring hospital… (moderate certainty).

1 finding from 1 review

Intervention not reported

SGRQ Scores range from 0 to 100, with higher scores indicating more limitations · 18 to 80 years of age with bronchiectasis

The intervention showed no clear difference in SGRQ Scores range from 0 to 100, with higher scores indicating more… (low certainty).

1 finding from 1 review

Intervention not reported

TDI Total scores range from ‐ 9 to +9. The lower the score, the greater the deterioration in severity of dyspnoea, MCID ≥ 1 · 18 to 80 years of age with bronchiectasis

The intervention may leads to higher TDI Total scores range from ‐ 9 to +9. The lower the score, the… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events-serious events Budesonide/formoterol (BDF) versus budesonide (BD) · patients with COPD

It is very uncertain whether the intervention changes adverse events-serious events Budesonide/formoterol (BDF) versus… (very low certainty).

1 finding from 1 review

Intervention not reported

Clinical failure (proportion of participants who were not cured or substantially improved (> 70% reduction in cough severity measure) at · children with subacute cough following acute bronchiolitis

The intervention showed no clear difference in clinical failure (proportion of participants who were not cured or… (low certainty).

1 finding from 1 review