Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,133 questions · 1,153 findings · 36 reviews · Skin

No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Bleach bath vs placebo or bath emollient

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with atopic dermatitis

Bleach bath showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with placebo or bath emollient (low certainty).

1 finding from 1 review

Topical antibiotics with steroids vs topical steroid

Minor adverse events not leading to withdrawal of treatment · people with eczema

It is very uncertain whether topical steroid plus topical antibiotic changes minor adverse events not requiring withdrawal from treatment compared with topical steroid (very low certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: investigator‐rated good/excellent control of symptoms · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: investigator‐rated good/excellent control of symptoms compared with vehicle foam (moderate certainty).

1 finding from 1 review

Corticosteroid creams/ointments: mometasone furoate cream 3 times/week vs 2 times/week

Secondary: investigator‐rated reduction in severity ‐ Not measured · people (all patch‐tested) with hand eczema > 6 months that had cleared upon daily treatment for a maximum of 9 weeks with mometasone…

The review found no eligible studies for this question.

1 finding from 1 review