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What do systematic reviews say?

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Evidence found and GRADE certainty

492 questions · 535 findings · 56 reviews · Hypertension

No studies found 37 · 6.9%GRADE not reported 34 · 6.4%Very low 91 · 17%Low 161 · 30.1%Moderate 136 · 25.4%High 76 · 14.2%

Angiotensin‐converting enzyme inhibitors vs ARB

Withdrawals due to adverse events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors leads to lower withdrawal due to adverse effects compared with all angiotensin receptor blockers (ARBs) (high certainty).

1 finding from 1 review

Intervention not reported

LDL‐Cholesterol rosuvastatin 2.5 mg/day · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

LDL‐Cholesterol rosuvastatin 5 mg/day · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

LDL‐Cholesterol rosuvastatin 10 mg/day · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

LDL‐Cholesterol rosuvastatin 20 mg/day · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

LDL‐Cholesterol rosuvastatin 40 mg/day · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

WDAE2 all doses · participantswith normal or abnormal lipid profiles
1 finding from 1 review

Intervention not reported

Total mortality Systolic targets · Diabetes Mellitus with elevated blood pressure

The intervention showed no clear difference in total mortality Systolic targets (low certainty).

1 finding from 1 review

Intervention not reported

Total mortality Diastolic targets · Diabetes Mellitus with elevated blood pressure

It is very uncertain whether the intervention changes total mortality Diastolic targets (very low certainty).

1 finding from 1 review

Intervention not reported

Total serious adverse events Systolic targets · Diabetes Mellitus with elevated blood pressure

The intervention showed no clear difference in total serious adverse events Systolic targets (low certainty).

1 finding from 1 review

Intervention not reported

Mortality 4 to 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes mortality 4 to 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Total CV events 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes total CV events 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse effects 5 years · Adults with mild hypertension and no cardiovascular disease

The intervention probably leads to higher withdrawals due to adverse effects 5 years (moderate certainty).

1 finding from 1 review