Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
Sealant + 5% NaF varnish was probably more effective than Sealant for arrest or reversal of occlusal carious lesions (RR 1.69, 95% CI 1.26 to 2.27; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
Resin infiltration may not differ from Resin infiltration + 5% NaF varnish for arrest or reversal of approximal carious lesions (RR 0.46, 95% CI 0.09 to 2.23; very low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
1.23% APF gel + oral health education was probably more effective than Oral health education for arrest or reversal of facial/lingual carious lesions (RR 2.47, 95% CI 1.95 to 3.13; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Resin infiltration + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.61, 95% CI 0.43 to 0.85; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
5% NaF varnish may be more effective than no treatment for arrest or reversal of facial/lingual carious lesions (RR 2.3, 95% CI 1.58 to 3.34; low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
5% NaF varnish was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.97, 95% CI 1.63 to 2.4; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.94, 95% CI 1.54 to 2.46; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
38% SDF + potassium iodide solution (applied annually) may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.8, 95% CI 0.05 to 11.95; very low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
1% chlorhexidine + 1% thymol varnish may not differ from 38% SDF solution (applied annually) for arrest or reversal of root carious lesions (RR 0.88, 95% CI 0.14 to 5.6; very low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
1% chlorhexidine + 1% thymol varnish may not differ from 5,000-ppm F (1.1% NaF) toothpaste or gel for arrest or reversal of root carious lesions (RR 0.64, 95% CI 0.15 to 2.7; very low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
Sealant + 5% NaF varnish was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 3.35, 95% CI 2.42 to 4.64; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
Resin infiltration + 5% NaF varnish may not differ from Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.95, 95% CI 0.75 to 1.21; low certainty).
1 finding from 1 review
All occlusal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled specificity for visual detection of all occlusal lesions was 0.770 (95% CI 0.73 to 0.81).
2 findings from 1 review
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Negative LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced proximal caries was 0.58 (95% CI 0.52 to 0.65) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, pooled specificity of visual detection for all (initial and advanced) occlusal caries was 75.3% (95% CI 70 to 80) (ungraded).
3 findings from 1 review
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Specificity 91.2 [88, 94]
12 studies
GRADE not reported
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
PPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of visual detection for advanced occlusal caries was 77.9% at an assumed prevalence of 22.0% (ungraded).
2 findings from 1 review
PPV 77.9
50 studies
GRADE not reported
PPV 30.6
55 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of radiographic detection for all (initial and advanced) occlusal caries was 91.4% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
NPV 91.4
9 studies
GRADE not reported
NPV 85.0
11 studies
GRADE not reported
Advanced proximal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled sensitivity for radiographic detection of advanced proximal lesions was 0.444 (95% CI 0.38 to 0.51).
8 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Show 5 more findings
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced occlusal caries was 0.53 (95% CI 0.46 to 0.62) (ungraded).
3 findings from 1 review
Negative LR 0.53 [0.46, 0.62]
44 studies
GRADE not reported
Negative LR 0.51 [0.44, 0.6]
38 studies
GRADE not reported
Negative LR 0.54 [0.46, 0.63]
36 studies
GRADE not reported
Sensitivity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for all (initial and advanced) occlusal caries was 49.1% (95% CI 40 to 58) (ungraded).
3 findings from 1 review
Sensitivity 49.1 [40, 58]
12 studies
GRADE not reported
Sensitivity 85.5 [81, 89]
67 studies
GRADE not reported
Sensitivity 85.8 [82, 89]
51 studies
GRADE not reported