Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,256 questions · 2,339 findings · 262 reviews

No studies found 555 · 23.7%GRADE not reported 398 · 17%Very low 572 · 24.5%Low 476 · 20.4%Moderate 240 · 10.3%High 98 · 4.2%

ALK inhibitor vs any cytotoxic chemotherapy

Health‐related quality of life: time to deterioration in composite endpoint (cough, dyspnoea, and chest pain) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor leads to lower health‐related quality of life: time to deterioration in composite… compared with any cytotoxic chemotherapy (high certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Paraesthesia · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in paraesthesia compared with phenytoin (low certainty).

1 finding from 1 review

Laminar air flow with HEPA filter vs Without laminar flow or filter

Reduction in level of contamination in aerosols (CFU per cubic feet/min/patient) using Reyniers slit sampler 30 inches (76 cm) from floor · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether laminar air flow with HEPA filter changes reduction in level of contamination in aerosols (CFU per cubic… compared with without laminar flow or filter (very low certainty).

1 finding from 1 review

Intervention not reported

Chest infections · patients with hip fracture

The intervention probably leads to lower chest infections (moderate certainty).

1 finding from 1 review

Intervention not reported

Other outcomes included uncertainty, pain, sexually related symptoms, dyspnoea, and general symptoms. Data for any of these outcomes were not pooled due to considerable heterogeneity across all aspects. Magnitudes of effect were not reported · individuals with any cancer at any stage
1 finding from 1 review

Rubber dam + HVE vs Cotton roll + HVE

Reduction in level of contamination in aerosols (CFU) during restorative procedures at participant's chest · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether rubber dam + HVE changes reduction in level of contamination in aerosols (CFU) during… compared with cotton roll + HVE (very low certainty).

1 finding from 1 review

Second‐generation endometrial ablation vs first‐generation endometrial ablation

Proportion given local anaesthesia (%) · heavy menstrual bleeding

It is very uncertain whether overall analyses: second‐generation endometrial ablation changes proportion given local anaesthesia (%) compared with first‐generation endometrial ablation (very low certainty).

1 finding from 1 review