Cochrane · systematic review · CD013551
Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding
Hayes, K, Fernando, MC, Jordan, V · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
14
No studies
2
Included studies
NR
No studies 2 · 12.5%Ungraded 0 · 0%Very low 6 · 37.5%Low 3 · 18.8%Moderate 5 · 31.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
PCC compared to standard treatment for cardiac surgery for the treatment of non‐surgical bleeding
Population: cardiac surgery for the treatment of non‐surgical bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood products transfused (RBC) in units PCC vs standard treatment | no estimate extracted | 2 studies · 151 participants | Moderate Downgraded: imprecision |
Blood products transfused (RBC) % of patients PCC vs standard treatment | OR 0.53 [0.2, 1.4] | 1 study · 101 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Thrombotic events PCC vs standard treatment | OR 0.68 [0.2, 2.31] | 2 studies · 152 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Mortality (30‐day) PCC vs standard treatment | OR 0.53 [0.12, 2.35] | 2 studies · 149 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Intensive care length of stay in hours PCC vs standard treatment | no estimate extracted | 2 studies · 151 participants | Moderate Downgraded: imprecision |
Incidence of renal impairment PCC vs standard treatment | OR 0.72 [0.14, 3.59] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Bleeding (chest drain output) in mLs for the first 12 hours PCC vs standard treatment | no estimate extracted | 2 studies · 151 participants | Low Downgraded: imprecision |
Adverse events PCC vs standard treatment | no estimate extracted | NR | No studies |
PCC compared to FVIIa for cardiac surgery for the treatment of non‐surgical bleeding
Population: cardiac surgery for the treatment of non‐surgical bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood products transfused (RBC) in units ‐ intraoperative PCC vs FVIIa | no estimate extracted | 2 studies · 256 participants | Moderate Downgraded: risk of bias |
Blood products transfused (RBC) % of patients PCC vs FVIIa | OR 0.16 [0.02, 1.56] | 1 study · 150 participants | Very low Downgraded: risk of bias |
Thrombotic events PCC vs FVIIa | OR 0.51 [0.23, 1.16] | 4 studies · 407 participants | Very low Downgraded: risk of bias |
Mortality (30‐day) PCC vs FVIIa | OR 1.07 [0.38, 3.03] | 3 studies · 278 participants | Very low Downgraded: risk of bias |
Bleeding (chest drain output) in mLs for the first 12 hours PCC vs FVIIa | no estimate extracted | 1 study · 150 participants | Very low Downgraded: risk of bias |
Intensive care length of stay in hours PCC vs FVIIa | no estimate extracted | 1 study · 106 participants | Very low Downgraded: risk of bias |
Incidence of renal impairment PCC vs FVIIa | OR 0.29 [0.12, 0.71] | 1 study · 106 participants | Very low Downgraded: risk of bias |
Adverse events PCC vs FVIIa | no estimate extracted | NR | No studies |