Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

643 questions · 693 findings · 156 reviews

No studies found 177 · 25.5%GRADE not reported 100 · 14.4%Very low 144 · 20.8%Low 139 · 20.1%Moderate 106 · 15.3%High 27 · 3.9%

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in probing depth (PD) (mm) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in clinical attachment level (CAL) (mm) compared with OFD (open flap debridement) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in graft loss or death with a functioning graft compared with steroid alone (moderate certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Treatment adverse events: UTI/pyelonephritis · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid probably leads to higher treatment adverse events: UTI/pyelonephritis compared with steroid alone (moderate certainty).

1 finding from 1 review

Antibody (T cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) + steroid changes graft loss or death with a functioning graft compared with steroid alone (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Complete response plus partial response Length of · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to higher complete response plus partial response Length of compared with TACE alone (low certainty).

1 finding from 1 review