Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

518 questions · 558 findings · 63 reviews

No studies found 77 · 13.8%GRADE not reported 143 · 25.6%Very low 89 · 15.9%Low 137 · 24.6%Moderate 95 · 17%High 17 · 3%

CPP-ACP vs No active treatment (control)

Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP increased Vickers microhardness versus control (SMD 1.19, 95% CI 0.72 to 1.66; ungraded).

3 findings from 1 review

CPP-ACP vs No active treatment (control)

Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).

1 finding from 1 review

Nimodipine vs placebo

Death at the end of · people with acute ischemic stroke

Nimodipine showed no clear difference in death at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Nimodipine showed no clear difference in recurrence of stroke at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Nimodipine showed no clear difference in adverse events during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Hypotension · people with acute ischemic stroke

Nimodipine showed no clear difference in hypotension during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Systolic blood pressure · people with acute ischemic stroke

Nimodipine showed no clear difference in mean systolic blood pressure during or at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Death or dependency at end of · people with acute ischemic stroke

Flunarizine showed no clear difference in death or dependency at end of compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Death at the end of treatment · people with acute ischemic stroke

Flunarizine showed no clear difference in death at the end of treatment compared with placebo (low certainty).

1 finding from 1 review