Neonatal mortality · neonates with possible serious bacterial infection
Comparison 2: any simplified antibiotic regimen showed no clear difference in neonatal mortality compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).
1 finding from 1 review
Treatment failure · neonates with possible serious bacterial infection
Comparison 2: any simplified antibiotic regimen showed no clear difference in treatment failure compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).
1 finding from 1 review
Adverse events · neonates with possible serious bacterial infection
Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).
1 finding from 1 review
No cure ‐ all trials · patients with asymptomatic bacteriuria during pregnancy
It is very uncertain whether single‐dose antibiotic changes no cure ‐ all trials compared with short‐course (four‐ to seven‐day) antibiotic (very low certainty).
1 finding from 1 review
Recurrent asymptomatic bacteriuria ‐ all trials · patients with asymptomatic bacteriuria during pregnancy
It is very uncertain whether single‐dose antibiotic changes recurrent asymptomatic bacteriuria ‐ all trials compared with short‐course (four‐ to seven‐day) antibiotic (very low certainty).
1 finding from 1 review
Pyelonephritis ‐ Same antimicrobial agent only4 · patients with asymptomatic bacteriuria during pregnancy
It is very uncertain whether single‐dose antibiotic changes pyelonephritis ‐ Same antimicrobial agent only4 compared with short‐course (four‐ to seven‐day) antibiotic (very low certainty).
1 finding from 1 review
Low birthweight ‐ Same antimicrobial agent only · patients with asymptomatic bacteriuria during pregnancy
Single‐dose antibiotic leads to higher low birthweight ‐ Same antimicrobial agent only compared with short‐course (four‐ to seven‐day) antibiotic (high certainty).
1 finding from 1 review
Preterm delivery ‐ Same antimicrobial agent only · patients with asymptomatic bacteriuria during pregnancy
Single‐dose antibiotic showed no clear difference in preterm delivery ‐ Same antimicrobial agent only compared with short‐course (four‐ to seven‐day) antibiotic (moderate certainty).
1 finding from 1 review
Side effects ‐ all trials · patients with asymptomatic bacteriuria during pregnancy
Single‐dose antibiotic may leads to lower side effects ‐ all trials compared with short‐course (four‐ to seven‐day) antibiotic (low certainty).
1 finding from 1 review
Same antimicrobial agent ‐ No cure (good quality studies) · patients with asymptomatic bacteriuria during pregnancy
Single‐dose antibiotic leads to higher same antimicrobial agent ‐ No cure (good quality studies) compared with short‐course (four‐ to seven‐day) antibiotic (high certainty).
1 finding from 1 review
Different antimicrobial agents ‐ No cure (good quality studies) · patients with asymptomatic bacteriuria during pregnancy
Single‐dose antibiotic showed no clear difference in different antimicrobial agents ‐ No cure (good quality studies) compared with short‐course (four‐ to seven‐day) antibiotic (low certainty).
1 finding from 1 review
Late‐onset blood steam infection · newborn infants undergoing removal of central venous catheter
Antibiotics on removal of central venous catheter showed no clear difference in late‐onset blood steam infection compared with no antibiotics (low certainty).
1 finding from 1 review
Neonatal mortality · newborn infants undergoing removal of central venous catheter
1 finding from 1 review
Mortality before hospital discharge · newborn infants undergoing removal of central venous catheter
1 finding from 1 review
Infection‐related mortality before hospital discharge · newborn infants undergoing removal of central venous catheter
1 finding from 1 review
Central line‐associated blood stream infection · newborn infants undergoing removal of central venous catheter
Antibiotics on removal of central venous catheter showed no clear difference in central line‐associated blood stream infection compared with no antibiotics (low certainty).
1 finding from 1 review
Clinical cure · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze
Antibiotic therapy showed no clear difference in clinical cure (symptomatic and clinical recovery by the end of… compared with placebo compared to placebo (moderate certainty).
1 finding from 1 review
Treatment failure (development of more severe signs and symptoms by the end of treatment) · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze
Antibiotic therapy may leads to lower treatment failure (development of more severe signs and symptoms by… compared with placebo compared to placebo (low certainty).
1 finding from 1 review
Relapse · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze
Antibiotic therapy showed no clear difference in relapse (children who were 'cured' but developed symptoms within… compared with placebo compared to placebo (low certainty).
1 finding from 1 review
FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
1 finding from 1 review