Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

Asthma Clinics (Intervention) vs controls

Number of participants experiencing one or more episodes requiring ED visit · people with asthma

It is very uncertain whether asthma Clinics (Intervention) changes A&E visits Number of people experiencing one or more A&E visit compared with controls (very low certainty).

1 finding from 1 review

Asthma Clinics (Intervention) vs controls

Hospital admissions · people with asthma

Asthma Clinics (Intervention) showed no clear difference in hospital admissions Number of people experiencing one or more… compared with controls (low certainty).

1 finding from 1 review

Monetary incentives vs usual care

Proportion of children who received the vaccine under study (measles/MMR) ‐ household monetary incentivef · children under 5 years of age

It is very uncertain whether monetary incentives changes proportion of children who received the vaccine under study… compared with routine care (very low certainty).

1 finding from 1 review

Monetary incentives vs usual care

Proportion of children who received the vaccine under study (MMR) ‐ service‐level monetary incentiveg · children under 5 years of age

It is very uncertain whether monetary incentives changes proportion of children who received the vaccine under study (MMR) ‐… compared with routine care (very low certainty).

1 finding from 1 review

Monetary incentives vs usual care

Proportion of children who received the vaccine under study (MMR) ‐ household + service‐level monetary incentive · children under 5 years of age

It is very uncertain whether monetary incentives changes proportion of children who received the vaccine under study (MMR) ‐… compared with routine care (very low certainty).

1 finding from 1 review

Intensive advocacy interventions for women who experience intimate partner abuse vs (Optimised) usual care

Overall abuse One study used a composite of two scales (12 items. Scale from 0 to 36) Other study used Composite Abuse Scale (CAS)i (30 items presented in a 6‐point format requiring respondents to answer 'never', 'only once', 'several times', 'mon... · women with intimate partner abuse
1 finding from 1 review

Summary of findings: insulin detemir vs Insulin glargin (control)

Percentage of participants having at least one severe hypoglycaemic event · patients with type 2 diabetes mellitus

Insulin detemir (intervention) showed no clear difference in percentage of participants having at least one severe hypoglycaemic… compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs Insulin glargin (control)

Percentage of participants having at least one hypoglycaemic event · patients with type 2 diabetes mellitus

Insulin detemir (intervention) showed no clear difference in percentage of participants having at least one hypoglycaemic event compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs Insulin glargin (control)

Injection‐site reaction Rates of patients · patients with type 2 diabetes mellitus

Insulin detemir (intervention) may leads to higher percentage of participants having at least one injection site reaction compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Bone marrow vs steroid injection

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · children with simple bone cysts

It is very uncertain whether bone marrow changes success rate (radiographically‐assessed healing of cyst healing… compared with steroid injections (very low certainty).

1 finding from 1 review